Results 81 to 90 of about 26,863 (267)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On the semicontinuity of curvatures
Commentarii Mathematici Helvetici, 1992 For a convex body \(K\) in \(\mathbb{R}^ n\) with a boundary of class \(C^ 2\) and positive curvatures and for \(\alpha\in\mathbb{R}\backslash\{0\}\) and \(j=1,\ldots,n-1\), let \[ \psi^ \alpha_ j(K)=\left\{{1\over\omega_ n}\int_{S^{n-1}}s_ j(K,u)^ \alpha d\omega(u)\right\}^{1/\alpha}, \] where \(s_ j(K,u)\) is the normalized \(j\)-th elementary ...
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Darboux Frame of Pancake Curve in Euclidean 3-Space
Cumhuriyet Science JournalIn this paper, we focus on a rare curve, “The pancake curve” which was named by Robert Ferréol. We investigate the Darboux frame of the curve, and we calculate the curvatures: geodesic curvature, normal curvature, and geodesic torsion.
Emre Öztürk
doaj +1 more source
Beltrami-Meusnier formulas of generalized semi ruled surfaces in semi Euclidean space
Kuwait Journal of Science, 2014 In this paper, we study the sectional curvatures of the generalized semi ruled surfaces in semi Euclidean space The first fundamental form and the metric coefficients of the generalized semi ruled surfaces are calculated and in these regards ...
MAHMUT AKYIG١IT +2 more
doaj
MOTION OF CURVES USING QUASI FRAME [PDF]
Assiut University Journal of Multidisciplinary Scientific Research, 2018 In this paper, evolution of space curves using quasi frame are considered. We derive a pair of coupled partialdifferential equations that governing the time evolution for the quasi curvatures of the evolving curve.
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
On the Sectional Curvature of Holomorphic Curvature Operators [PDF]
Proceedings of the American Mathematical Society, 1981 Guerrero, Ignacio, Zoltek, Stanley M.
openaire +2 more sources
Symmetry, Integrability and Geometry: Methods and Applications, 2007 The $(2k)$-th Gauss-Bonnet curvature is a generalization to higher dimensions of the $(2k)$-dimensional Gauss-Bonnet integrand, it coincides with the usual scalar curvature for $k = 1$.
Mohammed Larbi Labbi
doaj