Results 111 to 120 of about 870 (217)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exploring the incidence of dysplasia or adenocarcinoma in early onset Barrett's esophagus. [PDF]

Endoscopy
Noordzij IC, Huysentruyt CJ, Curvers WL, van Lijnschoten G, Masclee AAM, Schoon EJ.   +5 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

[Integrated cross-sectoral collaboration for pregnant women and (expectant) parents in a vulnerable situation: the Solid Start integrated approach in South Limburg, the Netherlands]. [PDF]

TSG
Smeets-Curvers N, Hendrix M, Daemers D, Drittij R, Levelink B, Stijnen M.   +5 more
europepmc   +1 more source

Participation in recreational activities varies with socioeconomic position and is associated with self-rated health and well-being. [PDF]

Prev Med Rep, 2021
Petersen CB, Bekker-Jeppesen M, Aadahl M, Lau CJ.   +3 more
europepmc   +1 more source

Dante et le Cercle de Colpach

peer reviewedAu travers de quelques correspondances et journaux édités, nous tentons d’objectiver l’intérêt que portent les écrivains à Dante, en particulier en passant par Pontigny et Colpach, et en particulier Paul Desjardins, André Gide (et la NRF ...
Gravet, Catherine
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The relation between Schneiderian membrane thickening and radiodiagnostic features of periapical pathology. [PDF]

Braz Dent J
Oliveira-Santos N, Leite AF, Petitjean E, Torres A, Van der Veken D, Curvers F, Pinto JC, Lambrechts P, Jacobsi R.   +8 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source