Results 61 to 70 of about 354,492 (314)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Instantons in non-Cartesian coordinates

, 2000
The explicit multi-instanton solutions by 'tHooft and Jackiw, Nohl & Rebbi are generalized to curvilinear coordinates. The idea is that a gauge transformation can notably simplify the expressions obtained after the change of variables.
A. A. Abrikosov, A. A. Belavin, A. Chodos, G. Hooft ’t, M. F. Atiah, R. Jackiw, T. Schäfer   +6 more
core   +2 more sources

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Asymptotic analysis of the Navier-Stokes equations in a curved domain with a non-characteristic boundary

Networks and Heterogeneous Media, 2012
We consider the Navier-Stokes equations of an incompressible fluid in a three dimensional curved domain with permeable walls in the limit of small viscosity.Using a curvilinear coordinate system, adapted to the boundary, we construct a corrector function
Gung-Min Gie, Makram Hamouda, Roger Temam   +2 more
doaj   +1 more source

Non-adiabatic mass correction to the rovibrational states of molecules. Numerical application for the H$_2^+$ molecular ion

, 2018
General transformation expressions of the second-order non-adiabatic Hamiltonian of the atomic nuclei, including the kinetic-energy correction terms, are derived upon the change from laboratory-fixed Cartesian coordinates to general curvilinear ...
Mátyus, Edit
core   +1 more source

Strain‐Assembled Crystalline SrRuO3 Microtube and Emergent Curvilinear Magnetism

Advanced Science, EarlyView.
The interfacial‐strain assembly based on planar nanomembranes presents a promising approach for constructing novel magnetic microstructures. By employing the perpendicular magnetic anisotropic SrRuO3 freestanding nanomembrane as a model system, we exploit the interfacial strain effect within the crystalline SrTiO3/SrRuO3 bilayer, and successfully ...
Lei Gao, Yuqian Wang, Xiangyu Lyu, Pengyu Liu, Mingtong Zhu, Jin Liu, Mengcheng Li, Ailing Ji, Qinghua Zhang, Lin Gu, Libo Ma, Zexian Cao, Nianpeng Lu   +12 more
wiley   +1 more source

Conditioning Electrical Stimulation for Patients with Moderate or Severe Carpal Tunnel Syndrome: Double Blinded Randomized Controlled Trial

Annals of Neurology, EarlyView.
Objective Carpal tunnel syndrome (CTS) can drastically impair one's ability to work and interferes with activities of daily living. We recently demonstrated that, in rodents, conditioning electrical stimulation (CES) delivered to the nerve 7 days prior to surgery imparts a conditioning lesion‐like effect by accelerating the rate of regeneration along ...
Yusuke Osaki, Jaret L. Olson, Michael J. Morhart, Matthew W. Curran, Douglas W. Zochodne, K. Ming Chan, on behalf of the Central and Northern Alberta Peripheral Nerve Injury Research Consortium, Hollie Power, Adil Ladak, Lindsay Hubenig, Alto Lo, Christine Webber, Karyne Rabey, Andrew Jack, Joe Watt, Mithun Rajshekar, Ellen Lee, Glyn Murgatroyd, Dan Yeung, Kathleen O'Grady   +19 more
wiley   +1 more source

A SHALLOW WATER MODEL FOR COMPUTING TSUNAMI ALONG THE WEST COAST OF PENINSULAR MALAYSIA AND THAILAND USING BOUNDARY-FITTED CURVILINEAR GRIDS [PDF]

Science of Tsunami Hazards, 2007
The west coast of Peninsular Malaysia and Thailand is curvilinear in nature and the bending is especially high along the coast of South Thailand. In hydrodynamic models for coastal seas, bays and estuaries, the use of boundary-fitted curvilinear grids ...
Md. Fazlul Karim, G D Roy, Ahmad Izani M Ismail, Mohammed Ashaque Meah   +3 more
doaj  

Exploring personality traits and mental toughness in early career teachers in England

British Educational Research Journal, EarlyView.
Abstract While some teachers thrive, in similar circumstances other teachers encounter considerable difficulties. This is particularly concerning in England, where high numbers of teachers with five or fewer years' experience leave the profession to take another job outside of teaching, and pupil numbers are outpacing teacher numbers (Bryan & Price ...
Joanne E. Taberner, Sarah MacQuarrie
wiley   +1 more source

Asymptotic solution for the Darcy-Brinkman-Boussinesq flow in a pipe with helicoidal shape [PDF]

Theoretical and Applied Mechanics, 2018
We study the fluid flow and heat transfer in a helical pipe filled with a sparsely packed porous medium. Motivated by the engineering applications, pipe’s thickness and the distance between two coils of the helix have the same small order of magnitude ...
Pažanin Igor
doaj   +1 more source