Endothelial progenitor cells in a patient with Cushing's syndrome before and after adrenal surgery
Endothelial progenitor cells (EPCs) exert a pivotal role in vascular repairing and vascular function. Low EPCs levels have been detected in patients with endocrine disease at increased cardiovascular risk such as diabetes, hypothyroidism, and ...
Roberto Negro
doaj +1 more source
Abstract Objective While cardiometabolic comorbidities have been well established in adults with polycystic ovary syndrome (PCOS), it remains unclear whether the early signs of cardiovascular morbidity emerge during adolescence. This study aimed to investigate whether metabolic and cardiovascular alterations begin in adolescents with PCOS.
Demet Aygün Ari +8 more
wiley +1 more source
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little +12 more
wiley +1 more source
Glucocorticoid therapies are extensively used in a wide range of medical conditions including respiratory, allergic, inflammatory and autoimmune diseases.
Sanjay Manubolu, MD, MPH +1 more
doaj +1 more source
Preclinical Cushing's syndrome in adrenal incidentalomas [PDF]
Adrenal tumors are usually diagnosed by clinical symptoms of hormone excess. The increasing use of ultrasound and computed tomography results in the detection of a substantial number of incidentally discovered adrenal tumors.
Allolio, B. +5 more
core
Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review
ABSTRACT In recent years, innovative topical medications with novel mechanisms of action have emerged to treat common dermatologic conditions such as acne, atopic dermatitis, vitiligo, and actinic keratoses. These molecularly targeted therapies offer improved safety and tolerability compared to traditional options like corticosteroids.
Mary Dyson +4 more
wiley +1 more source
Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro [PDF]
In a substantial part of adrenal adenomas and hyperplasias from patients with Cushing's syndrome, cortisol production is controlled by the expression of aberrant hormone receptors on adrenocortical cells.
Bonjer, H.J. (Jaap) +10 more
core +9 more sources
Clonal Composition of Human Adrenocortical Neoplasms [PDF]
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Abdelhamid, S. +7 more
core
Complications of Cushing's syndrome: state of the art [PDF]
Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities.
Biller, Beverly M. K +5 more
core +1 more source
Diagnostic orientation values for ACTH and other parameters for clinically healthy donkeys and mules (insulin, triglycerides, glucose, fructosamines, and ɣ‐GT) [PDF]
Pituitary pars intermedia dysfunction is the most prevalent endocrine disease in horses. Although donkeys and mules may also be affected, only a few data have been published. Reference values for diagnostic parameters, such as adrenocorticotropic hormone
Bartmann, Claus P. +4 more
core +1 more source

