The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing mice
Vivek Bhaskaran +15 more
doaj +1 more source
The Eosinophil Count Tends to Be Negatively Associated with Levels of Serum Glucose in Patients with Adrenal Cushing Syndrome [PDF]
BackgroundCushing syndrome is characterized by glucose intolerance, cardiovascular disease, and an enhanced systemic inflammatory response caused by chronic exposure to excess cortisol.
Younghak Lee +9 more
doaj +1 more source
Steroids in pediatric eosinophilic esophagitis [PDF]
Swallowed fluticasone and oral viscous budesonide are effective first-line therapies for eosinophilic esophagitis in children. Side effects are minimal without evidence of Cushing syndrome, as seen in treatment with systemic corticosteroids.
Contreras, Emily M., Gupta, Sandeep K.
core +1 more source
Diabète endocrine: mise au point à propos d´un cas de maladie de Cushing
Le diabète sucré peut survenir au cours de nombreuses endocrinopathies. Il résulte d'un effet direct ou indirect de l'hormone présente en excès sur le métabolisme glucidique. Nous rapportons un cas de diabète secondaire à une maladie de Cushing.
Amadou Diop Dia +3 more
doaj +1 more source
Three New Cool Brown Dwarfs Discovered with the Wide-field Infrared Survey Explorer (WISE) and an Improved Spectrum of the Y0 Dwarf WISE J041022.71+150248.4 [PDF]
As part of a larger search of Wide-field Infrared Survey Explorer (WISE) data for cool brown dwarfs with effective temperatures less than 1000 K, we present the discovery of three new cool brown dwarfs with spectral types later than T7.
Cushing, Michael C. +5 more
core +3 more sources
A patient with Cushing disease lateralizing a pituitary adenoma by inferior petrosal sinus sampling using desmopressin: a case report [PDF]
A 14-year-old girl was referred for evaluation of the etiology of Cushing syndrome. During the previous 2 years, she had experienced weight gain, secondary amenorrhea, growth retardation, and back pain.
Joo Hee Lim +7 more
doaj +1 more source
New H2 collision-induced absorption and NH3 opacity and the spectra of the coolest brown dwarfs [PDF]
We present new cloudy and cloudless model atmospheres for brown dwarfs using recent ab initio calculations of the line list of ammonia (NH3) and of the collision-induced absorption of molecular hydrogen (H2).
Ackerman +69 more
core +2 more sources
We report an adolescent boy diagnosed with ectopic adrenocorticotropin hormone syndrome (EAS) due to an atypical bronchial carcinoid. The patient was managed by a multidisciplinary team.
Sema Nilay Abseyi +7 more
doaj +1 more source
ULAS J141623.94+134836.3: a Blue T Dwarf Companion to a Blue L Dwarf [PDF]
We confirm the substellar nature of ULAS J141623.94+134836.3, a common proper motion companion to the blue L dwarf SDSS J141624.08+134826.7 identified by Burningham et al. and Scholz.
Abazajian +46 more
core +2 more sources
Ectopic Cushing’s syndrome triggering a bipolar affective disorder [PDF]
Objective To report the case of a patient with Cushing’s syndrome (CS) resulting from an ectopic tumor producing adrenocorticotropic hormone (ACTH) in an unusual topography, triggering bipolar affective disorder (BAD) in a previously healthy patient ...
Adriano Fernandes de Mendonça +4 more
doaj +1 more source

