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Cushing's syndrome: Overview of clinical presentation, diagnostic tools and complications.

Best practice & research. Clinical endocrinology & metabolism, 2020
Cushing's syndrome (CS) is a severe condition that results from chronic exposure to elevated circulating cortisol levels; it is a rare but potentially life-threating condition, especially when not timely diagnosed and treated.
M. Barbot, M. Zilio, C. Scaroni
semanticscholar   +1 more source

Advances in the medical treatment of Cushing's syndrome.

The Lancet Diabetes and Endocrinology, 2019
Cushing's syndrome is associated with multisystem morbidity and, when suboptimally treated, increased mortality. Medical therapy is an option for patients if surgery is not successful and can be classified into pituitary-directed drugs, steroid synthesis
R. Feelders   +5 more
semanticscholar   +1 more source

The incidence of endogenous Cushing's syndrome in the modern era

Clinical Endocrinology, 2019
Epidemiological studies on the incidence of Cushing's syndrome (CS) are few and most often includes only patients with the most common form, that is Cushing's disease (CD).
Sofie Wengander   +3 more
semanticscholar   +1 more source

Doença de Cushing e o impacto cardiometabólico do diagnóstico tardio: uma revisão integrativa

Brazilian Journal of Development
A Doença de Cushing (DC) é uma patologia multissistêmica grave, caracterizada pelo hipercortisolismo endógeno crônico, que impõe severos riscos à homeostase orgânica.
A. Costa   +3 more
semanticscholar   +1 more source

Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial.

The Lancet Diabetes and Endocrinology, 2019
BACKGROUND Levoketoconazole is a ketoconazole stereoisomer in development for treatment of Cushing's syndrome and has not been assessed previously in a clinical trial in patients with Cushing's syndrome. We aimed to investigate the efficacy and safety of
M. Fleseriu   +10 more
semanticscholar   +1 more source

Diagnosis of Cushing's Syndrome in the Modern Era.

Endocrinology and metabolism clinics of North America (Print), 2018
Four challenges complicate the evaluation for Cushing syndrome. These challenges include increasing global prevalence of obesity and diabetes; increasing use of exogenous glucocorticoids, which cause a Cushing syndrome phenotype; the confusion caused by ...
L. Nieman
semanticscholar   +1 more source

An individualized approach to the management of Cushing disease

Nature Reviews Endocrinology, 2023
M. Fleseriu   +4 more
semanticscholar   +1 more source

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