Identification of recurrent USP48 and BRAF mutations in Cushing’s disease
Nature Communications, 2018 Cushing’s disease results from corticotroph adenomas of the pituitary that hypersecrete adrenocorticotropin (ACTH), leading to excess glucocorticoid and hypercortisolism. Mutations of the deubiquitinase gene USP8 occur in 35–62% of corticotroph adenomas.
Jianhua Chen +39 more
semanticscholar +1 more source
Research Communications of the 29th ECVIM‐CA Congress
, 2020 Journal of Veterinary Internal Medicine, Volume 34, Issue 1, Page 339-445, January/February 2020.
wiley +1 more source
The incidence of Cushing’s disease: a nationwide Swedish study
Pituitary, 2019 BackgroundStudies on the incidence of Cushing’s disease (CD) are few and usually limited by a small number of patients. The aim of this study was to assess the annual incidence in a nationwide cohort of patients with presumed CD in Sweden.MethodsPatients
O. Ragnarsson +22 more
semanticscholar +1 more source
Efficacy and safety of once-monthly pasireotide in Cushing's disease: a 12 month clinical trial.
The Lancet Diabetes and Endocrinology, 2018 BACKGROUND Cushing's disease is a rare debilitating endocrine disorder for which few prospective interventional studies have been done. We report results of the first phase 3 trial assessing long-acting intramuscular pasireotide in patients with Cushing ...
A. Lacroix +14 more
semanticscholar +1 more source
Iatreia, 2005 The role of abnormalities of the hypophysishypothalamus- adrenal gland axis (HHA) in the ongoing stress and depression is analyzed. Besides, it is evidenced that some problems, until recently considered merely endocrine-metabolic such as Cushing's ...
Leidy Alexandra Lezcano Tobón +3 more
doaj
The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.
Journal of Clinical Endocrinology and Metabolism, 2008 OBJECTIVE The objective of the study was to develop clinical practice guidelines for the diagnosis of Cushing's syndrome. PARTICIPANTS The Task Force included a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society ...
L. Nieman +6 more
semanticscholar +1 more source
Neuroendocrine Axis of Stress, Metabolic Syndrome and Psychiatric Disorders in Cushing's Sindrome [PDF]
, 2005 RESUMEN: Se analiza el papel de las anormalidades del eje hipotálamo-hipófisis-adrenales (HHA) en el estrés sostenido y la depresión. Además se pone en evidencia que algunos problemas hasta hace poco considerados puramente endocrino-metabólicos como el
Gómez Franco, Juliana +3 more
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Approach to patients with pseudo-Cushing’s states
Endocrine Connections, 2019 The distinction between pseudo-Cushing’s states (PCS) and Cushing’s syndrome (CS) poses a significant clinical challenge even for expert endocrinologists.
C. Scaroni +9 more
semanticscholar +1 more source
Octreotide + bilateral adrenalectomy in the management of ACTH-producing carcinoid tumors [PDF]
, 2005 A síndrome de Cushing (SC) por ACTH ectópico é um distúrbio com alta morbi/mortalidade, cujo manejo necessita de medidas terapêuticas rápidas e eficientes.
Czepielewski, Mauro A. +11 more
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Holocene environmental change through natural processes and human influence in Salento, South-East Italy : an integrated geomorphological and palynological investigation. [PDF]
, 1992 South-east Italy is a region of distinct archaeological importance in which environmental factors have clearly played a major role in settlement site selection and economic development throughout the Holocene.
Harding, Jenny Lynne
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