Results 181 to 190 of about 9,663 (352)
Clinical Pharmacology &Therapeutics, EarlyView.Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano +8 more
wiley +1 more source
Mitral restenosis in the early postoperative period of a patient with systemic lupus erythematosus
Arquivos Brasileiros de Cardiologia, 1999 A forty eight year old woman, who had undergone mitral comissurotomy and subsequently developed early restenosis, presented with major comissural fusion and verrucous lesions on the cuspid edges of the mitral valve, with normal subvalvar apparatus ...
Pomerantzeff Pablo Maria Alberto +4 more
doaj
Clinical Pharmacology &Therapeutics, EarlyView.Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe +4 more
wiley +1 more source
A shark-inspired general model of tooth morphogenesis unveils developmental asymmetries in phenotype transitions. [PDF]
Proc Natl Acad Sci U S A, 2023 Zimm R +3 more
europepmc +1 more source
“Quadricuspidization” of a Previously Three-Cuspid Aortic Valve
, 2023 Jessica M. Mann, William C. Roberts
openalex +1 more source
Developmental Dynamics, EarlyView.Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito +9 more
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Romanian Journal of Oral Rehabilitation, 2011 In contemporary dental care an increased number of adult patients are seeking orthodontic treatment. In such adult patients, a combined orthodontic and other specialized therapy often offers the best options for achieving a predictable outcome to solve ...
Loredana Golovcencu, +2 more
doaj
Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges
Epilepsia Open, EarlyView.Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus +7 more
wiley +1 more source
Case Report No.2: Non-Extraction Treatment of a Class II Malocclusion including Upper Cuspid Exclusion. [PDF]
, 1994 Pedley Ronald J
openalex +1 more source