Results 141 to 150 of about 549,423 (267)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Salvage of Infected Dynamic Hip Screw and Distal Femur Nail Fixation for Ipsilateral Femoral Neck and Femoral Shaft Fracture Using Antibiotic-Coated Custom Long-Stem Austin Moore Prosthesis - A Rare Case Report. [PDF]

J Orthop Case Rep
Das J, Sabat N, Rathod AS, Kumar P, Barman J, Sonune SS.   +5 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Use of Custom-Designed Additive-Manufactured Acetabular Components for Reconstruction of Paprosky Type III Acetabular Defects in Revision Hip Arthroplasty: A Single-Center Case Series. [PDF]

J Clin Med
Belokobylov AA, Serikbayev VD, Petrovsky KA, Novik EA, Azamatov BN, Alzhanov YE, Sultanov DB, Spichag LV.   +7 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Change in refractive outcomes after custom, flexible iris prostheses placed secondarily within the capsular bag. [PDF]

J Cataract Refract Surg
Tuzun SE, Snyder ME.
europepmc   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Are Patient-Specific 3-Dimensionally Printed Instrumentations a Viable Solution to Safe Cortical Bone Trajectory Screw Placement? A Systematic Review. [PDF]

Int J Spine Surg
Ehioghae M, Japa JP, Yoon K, Benn L, Alshomali A, Hyde J, Bae S, Farhan-Alanie M, Mesfin A, Tannous O.   +9 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Cranioplasty with a 3D-printed titanium implant for post-decompressive craniectomy syndrome: A case report. [PDF]

Surg Neurol Int
Tran V.
europepmc   +1 more source