Results 191 to 200 of about 374,969 (306)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

open access: yesAdvanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto   +11 more
wiley   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

open access: yesAdvanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber   +12 more
wiley   +1 more source

Lingual nerve injuries: recognized complications or preventable errors? [PDF]

open access: yesFront Oral Health
Van der Cruyssen F   +2 more
europepmc   +1 more source

Ejecta‐Modulated Bubble Dynamics Play a Dominant Role in Stone Retropulsion

open access: yesAdvanced Science, EarlyView.
Stone motion during laser ablation is shown to result primarily from asymmetric cavitation bubble collapse, not from ejecta recoil. This challenges long‐standing assumptions and highlights the dominant role of bubble dynamics in laser–material interactions.
Obed S. Isaac   +4 more
wiley   +1 more source

Spectral‐Integrated Thermal Absorption Model for Broadband Laser‐Protective Reflectors Under Supercontinuum Irradiation

open access: yesAdvanced Science, EarlyView.
A universal laser absorption model based on spectral integration enables the design of ultrabroadband dielectric multilayer reflectors for laser protection. The model reveals exponential decay of absorption characterized by two coefficients, and a design that prioritizes short‐wavelength reflection minimizes heating.
Yukang Feng   +8 more
wiley   +1 more source

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