Results 71 to 80 of about 438,552 (304)

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

PABRE-Proj: applying patterns in requirements elicitation [PDF]

, 2013
© 2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes,creating new ...
Franch Gutiérrez, Javier, Palomares Bonache, Cristina, Quer, Carme   +2 more
core   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Students\u27 use of personal technology in the classroom: analyzing the perceptions of the digital generation [PDF]

, 2016
Faculty frequently express concerns about students’ personal use of information and communication technologies in today’s university classrooms. As a requirement of a graduate research methodology course in a university in Ontario, Canada, the authors ...
Kolpin, Samantha Lynn, Langan, Debra A., Dr., Lopez, Carla, Schott, Nicole D, Smith, Daniel, Szeto, Justin K., Wykes, Timothy G   +6 more
core   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

TRIMATRA UNTUK MEMENANGKAN PERSAINGAN: VALUE, KUALITAS JASA, DAN DELIGHT

Benefit Jurnal Manajemen dan Bisnis, 2009
Emulation level which progressively tightened to cause every organization should be able to give superior value to customer. Organization should be able to give the service quality such as those which wanted by the customer, not solely pursuant to ...
Sholihati Amalia, Sri Raharso
doaj  

Psychological contract and knowledge management mediated by cultural dynamics [PDF]

, 2012
Contact centres are the vital link in the value chain between the organisation and its customers because they offer essential front line sales and services of products.
Parikh, Vishal, Walton, John
core  

VCSEL-based, CWDM - PON systems using reflective technology for bi-directional multi-play service provision [PDF]

, 2012
Orthogonal frequency division multiplexing based on radio-overfiber schemes allows the direct use of multiple, native format wireless platforms. In combination with standard baseband provision such as Gigabit Ethernet, this provides access to a wide ...
Dudley, Sandra, Llorente, Roberto, Morant, Maria, Quinlan, Terence, Walker, Stuart   +4 more
core   +2 more sources

A Fully Self‐Powered Digital Wearable System for the Auxiliary Treatment of Plantar Fasciitis

Advanced Science, EarlyView.
This study reports a system‐level fully self‐powered digital wearable system (FS‐DWS) for the auxiliary treatment of plantar fasciitis. By integrating arch support, energy harvesting, wearable sensing, and machine learning‐driven closed‐loop visualized feedback, the system enables effective plantar pressure reduction and self‐powered, real‐time plantar
Jiacheng Hou, Ying Hong, Shiyuan Liu, Qiqi Pan, Jingyu Zhang, Qingyang Xu, Qiyi Nie, Zhonghe Wang, Liming Xin, Yilong Wang, Biao Wang   +10 more
wiley   +1 more source