Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
PRELIMINARY INFORMATION AS A FORM OF INFORMATION SUPPORT FOR ACTIVITIES OF CUSTOMS ADMINISTRATIONS
Larysa Fedoryshyna
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Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Challenges in radiopharmaceutical importation across six Southern African Development Community countries: an exploratory study. [PDF]
Mkhombo VG, Mosima L, Summers B.
europepmc +1 more source
Customs Administration Reform and Modernization in Francophone Sub-Saharan Africa, 1995-2010
Gilles Montagnat-Rentier, Gilles Parent
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Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Epidemiological investigation of an acute gastroenteritis outbreak associated with norovirus GΙΙ.17[P17] in a cross-border travel group - Shanghai Port, China, 2024. [PDF]
Liu D +15 more
europepmc +1 more source
Proposal for a Council Regulation (EEC) opening, allocating and providing for the administration of a Community tariff quota for rum, arrak and tafia falling within subheading 22.09 C I of the Common Customs Tariff and originating in the overseas countries and territories associated with theEuropean Economic Community (1981/1982) (submitted to the Council by the Commission). COM (81) 204 final, 29 April 1981 [PDF]
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