Results 181 to 190 of about 14,356 (250)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Virome profiling of Aedes albopictus across urban ecosystems in Guangdong reveals sex-specific diversity. [PDF]

Parasit Vectors
Li Q, Huang J, Zhou Y, Wu Q, Zhou J, He F, He L, Shi Y, Guo C, Dai J.   +9 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

VirPhyKit: An Integrated Toolkit for Viral Phylogeographic Analysis. [PDF]

Ecol Evol
Yin Y, Shen J, Du Z, Ho SYW, Gao F.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Comments on: "Pain Lateralization in Cluster Headache and Associated Clinical Factors". [PDF]

J Clin Neurol
Kazmi S, Iqbal M, Ui Haq MZ.
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Women's Perceptions on Newborn Care Practices, Knowledge Sources, Benefits, and Challenges in Rural Northern Jordan: A Qualitative Study. [PDF]

Healthcare (Basel)
Alrabab'a MH, Maabreh RS, Yehia DB, Eyadat AM, Ashour A, Bani Hani S, Mohammad AA, Alsharairi NA, Alkhsealat Y, Abusbaitan H, Alali WT.   +10 more
europepmc   +1 more source

A novel UPLC-based method to identify elephant and mammoth ivory. [PDF]

Sci Rep
Su C, Xie Y, Wang B, Cui L, Liu B, Zhou Y, Yang S, Zhang L, Xu Y.   +8 more
europepmc   +1 more source