Results 271 to 280 of about 1,779,882 (345)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Strengthening systems to monitor antibiotics. An action oriented approach. [PDF]

Wellcome Open Res
Valsson O, Tayler E, Kitutu FE, Bonnah J, Cornejo J, Dorado Garcia A, Dreser A, Echeverria A, Essack SY, Fenwick S, Fuller W, Hanna N, Hegewisch-Taylor J, Holloway B, Jeannin M, Joshi J, Kainga H, Khurana A, Koya SF, Larsson DGJ, Lekagul A, Lwoyero J, Masika S, Mateus ALP, Mitambo C, Moremi N, Muloi D, Ndahi M, Nkansa M, Nkhoma J, Odeo S, Ondoa P, Sharland M, Tigulini de Souza Bogo R, Sternberg-Lewerin S, Verhaegen M, Verner-Jeffreys D, Weese JS, Yamba K, Yesmin SMS, Midega J, Chandler CIR.   +41 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Location selection of emergency support and logistics centers under complex urban infrastructure disruptions. [PDF]

Sci Prog
Kara B, Cari M, Kudret Karaca T, Yalcin Kavus B, Ayyildiz E.   +4 more
europepmc   +1 more source

Positive Integration and Positive Youth Development With Adolescents and Young Adults Who Are Refugees or Migrants. [PDF]

J Adolesc Health
Oscós-Sánchez MÁ, Barral RL, Castro-Ramírez F, McPherson LE, Morris DE, Raymond-Flesch M, Svetaz MV.   +6 more
europepmc   +1 more source

Strengthening tobacco control enforcement in Nigeria: a policy and regulatory analysis supporting an expanded mandate for NAFDAC. [PDF]

BMC Public Health
Sani SK, Momodu R, Umar AB, Ashiru AY, Ibrahim IG.   +4 more
europepmc   +1 more source

Strategies for Managing Marburg Virus Disease Outbreaks: Lessons from the Rwanda Outbreak. [PDF]

Infect Drug Resist
Muvunyi CM, Iradukunda PG, Gashema P, Azhary A, Taha Osman Ali E, Siddig EE, Harelimana JD.   +6 more
europepmc   +1 more source

Open carry. [PDF]

Fly (Austin)
Jacobs H.
europepmc   +1 more source

Arab Medical Tourists in Iran: A Phenomenological Study of Lived Experience. [PDF]

Health Sci Rep
Shaygani F, Marzaleh MA, Movahed PD, Bahrami MA, Mohamadpour M, Delavari S.   +5 more
europepmc   +1 more source