Results 51 to 60 of about 6,783 (215)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Formation and management of budget flows by custom’s authorities of Russian Federation

open access: yesRUDN Journal of Economics, 2015
In the article there are described the problems, connected with the budgetary flours’ formation mechanism as the result of the cooperation between the customs organs and the participants VED. The author reveals the special feature of the formation of two
E A Morozova
doaj  

Selected Legal Aspect of Environmental Protection in the Context of the Reform of Europeanunion Customs Law

open access: yesFinancial Law Review
The paper explores the legal and institutional dimensions of environmental protection within the ongoing reform of the European Union’s customs law.
Peter Kuko
doaj   +1 more source

Legal measures to counteract smuggling a nd violations of customs rules on transport: the modern state

open access: yesLex Portus, 2019
The article is devoted to the research of modern issues of organizational and legal means of combating smuggling and violation of customs rules in transport.
Dopilko V., Yavdoschuk R.
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Cross-Border Interaction between Kazakhstan and Uzbekistan in Logistics: Conceptual Approaches

open access: yesЭкономика: стратегия и практика
The article examines cross-border cooperation between Kazakhstan and Uzbekistan, focusing on developing logistics in border regions. Central Asian regions face significant barriers, such as logistical inefficiencies, legal and customs discrepancies, and ...
G. Bodaubayeva   +3 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Simplification of International Trade Procedures as Result of a Customs Cooperation

open access: yesÈkonomika, Pedagogika i Pravo, 2016
In this article on the basis of result of the research conducted by the author importance of questions of simplification of procedures of trade for stimulation of growth and development of world economy is proved.
Aminat A. Bishenova
doaj  

THE POLICY OF ECONOMIC RELATIONS BETWEEN TURKEY AND THE EUROPEAN UNION [PDF]

open access: yesEconomy and Sociology, 2015
A Customs Union came into force on 31 December 1995. The Customs Union covers all industrial goods but does not address agriculture (except processed agricultural products), services or public procurement.
Bestenigar KARA   +2 more
doaj  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy