Results 121 to 130 of about 216,353 (309)

Access to Medicines: the Role of Intellectual property Law and Policy [PDF]

, 2012
Intellectual property (IP) policy is an important structural determinant of health. Patent policy influences the rate and direction of innovation for health, playing a positive or negative role depending on how it is shaped and implemented.
El Said, Mohammed, Kapczynski, Amy
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

‘We are no longer prepared to be silent’

Suomen Antropologi, 2010
In April 2008, at the annual session of the Permanent Forum for Indigenous Issues in New York, indigenous peoples celebrated the adoption of the UN  Declaration on the Rights of Indigenous Peoples (2007). The approval of the UN Declaration was seen as a
Irja Seurujärvi-Kari
doaj  

An Evaluation of the Need and Cost of Selected Trade Facilitation Measures in India: Implications for the WTO Negotiations [PDF]

The study finds that in case of Article X, which basically deals with the publication and administration of trade regulations, India has already implemented most of the requirements.
Sachin Chaturvedi
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

DIGITAL TRANSFORMATION OF THE CUSTOMS SPHERE IN THE CONDITIONS OF THE FORMATION OF THE DIGITAL SPACE OF EAEU

Цифровая трансформация, 2018
The role of digital transformation in the general picture of the formation of the digital space of EAEU is analyzed. The main world trends, which testify to the process of introduction of digital technologies in the customs sphere, are also highlighted ...
A. V. Shimanskaja
doaj   +2 more sources

Theoretic ndash; practical analysis of the detailed customs declaration

, 2020
Prezentul articol aduce în prim plan definirea şi analiza declaraţiei vamale în detaliu. Orice persoană, fizică sau juridică, indiferent de forma de proprietate, este în drept să introducă şi să scoată din ţară mărfuri şi mijloace de transport conform legislaţiei în vigoare, iar la trecerea peste frontieră a acestora sunt supuse declarării organului ...
Ursu, V., Stamati, M.
openaire   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Application of the customs procedure of processing in the customs territory when performing foreign trade operations

Вестник университета
The relevance of the research topic lies in the fact that the customs procedure of processing in the customs territory, which allows the use of imported goods in products manufacture for export without paying customs duties and taxes, becomes the object ...
E. A. Lysenko, S. V. Fomin
doaj   +1 more source