Results 211 to 220 of about 216,353 (309)

Overlooked toll of climate change on migrant children in the Americas. [PDF]

Nat Clim Chang
Pintea S, Acevedo A, Horenziak J, Kurani A, Kohli K, Wang S, Richardson ET, Introcaso D, Marrero A.   +8 more
europepmc   +1 more source

Customary International Law: What It Is and What It Is Not [PDF]

, 2011
Cabranes, José A.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A stamp of approval is not a seal of ethics: an editorial on justice and respect in trial design. [PDF]

Trials
Goldstein CE, Treweek S, Fatemian H.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Addressing the legal and health challenges of licensed medical cannabis users who want to travel abroad. [PDF]

Isr J Health Policy Res
Bonny-Noach H, Ne'eman-Haviv V.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effectiveness of Ethnic-Cultural Educational Strategies for the Promotion of Breastfeeding. [PDF]

Int J Environ Res Public Health
Hidrobo-Guzmán JF, Morejón-Jácome GE, Cárdenas-Robles ED, Pilco-Vargas LD, Posso López DV, Iguago Angamarca ET.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

SIAP: Synthetic dataset for maritime vessel risk profiling and illegal activity prediction. [PDF]

Data Brief
Karamolegkos S, Dourvas NΙ, Episkopos N, Pikounis K, Michail E, Ioannidis K, Vrochidis S.   +6 more
europepmc   +1 more source