Results 191 to 200 of about 2,275,229 (243)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

French University Dress: Regulations and Custom

Transactions of the Burgon Society, 2002
openaire   +2 more sources

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FEATURES OF CUSTOMS AND TARIFF REGULATION

Поколение будущего: сборник избранных статей Международной студенческой научной конференции (Санкт-Петербург, Ноябрь 2021), 2022
В данной статье рассматриваются особенности таможенно-тарифного регулирования в условиях ЕАЭС. В связи с тем, что таможенно-тарифное регулирование является одним из методов государственного регулирования внешнеторговой деятельности, оно является неотъемлемой частью таможенно-тарифной системы в целом.
openaire   +1 more source

Regulation at the Customer's Tap

Journal AWWA, 1988
This article discusses the problems, both legal and practical, of water utilities being regulated at the tap by the US Environmental Protection Agency. As the Safe Drinking Water Act (SDWA) amendments are now written, the point at which the water supplying utility will be regulated (the treatment plant or the tap) is ambiguous.
openaire   +1 more source

Regulation and Customer Engagement

Economics of Energy & Environmental Policy, 2012
The utility regulation framework developed in the UK in the 1980s, and widely adopted internationally, was intended to improve on the restrictive, inefficient and burdensome regulatory approach in the US. But the UK regulatory process has itself now become increasingly burdensome.
openaire   +1 more source

Legal regulation of the customs procedure of the free customs zone in the EAEU

Lizing (Leasing), 2021
In this article, the author analyzes the application of the customs procedure of the free customs zone in the space of the Eurasian Economic Union. The legal framework was considered as a regulative factor, taking into account a territorial aspect.
openaire   +1 more source