Results 151 to 160 of about 915 (214)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source
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Valuing customers

BT Technology Journal, 2005
This paper considers the metric of customer lifetime value as a way of placing an expected future value on a company's customers. This approach looks at the fundamental contribution a customer makes to a company's profits. The basic concept is useful in its own right, but it also allows an analogue between a customer and the equity of the company to be
D. Collings, N. Baxter
openaire   +1 more source

Customer value metrics

2008
This paper focuses on customer value analysis and measurement, framing customer value management as one of the main antecedents of the company value-creation process. The paper builds on three main pillars. First, the paper highlights the critical role of customer value in business-to-business markets, focusing on the links between the company’s ...
BUSACCA, BRUNO GIUSEPPE   +2 more
openaire   +3 more sources

Valuing Customers

SSRN Electronic Journal, 2003
It is increasingly apparent that the financial value of a firm depends on off-balance-sheet intangible assets. In this article, the authors focus on the most critical aspect of a firm: its customers. Specifically, they demonstrate how valuing customers makes it feasible to value firms, including high-growth firms with negative earnings.
Sunil Gupta   +2 more
openaire   +1 more source

Customer Lifetime Value

2002
In diesem Beitrag wird zunachst der Begriff Customer Lifetime Value (CLV) erlautert. Anschliesend wird seine Berechnung anhand von einfachen Zahlenbeispielen erklart. Diese Beispiele zeigen auch die Schwierigkeit auf, will man in der Praxis einzelne Kunden oder Kundensegmente anhand dieses Wertes beurteilen.
Gierl, Heribert, Koncz, Julia
openaire   +1 more source

Customer Value Creation

2019
The concept customer value has many meanings (Woodall 2003), but, from a marketing theory, two dominate: customer value refers to customers’ perceptions of what they receive and in return for what they sacrifice (Zeithaml 1988). The creation of customer value has long been recognized as a central concept in marketing (Woodruff 1997)
openaire   +2 more sources

Unearthing Customer Value

2017
In this chapter we will look at: • Why a theme-based approach to value propositions is beneficial • How to get to the key themes and issues affecting your customers • Understanding what drives change (Industry themes versus individual customer issues) • The mixed method approach to gathering customer intelligence • Tips to get ...
Simon Kelly   +2 more
openaire   +1 more source

Customer Value and Customer Selection

2014
The fact that the establishment and cultivation of business relationships require substantial resources, raises the question whether those investments are compensated by the earnings achieved. To answer this question, it is necessary to determine the value of single customers and to make decisions on how to select and shape the relationship with them ...
openaire   +1 more source

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