Results 191 to 200 of about 5,792,626 (248)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

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Customer value metrics

2008
This paper focuses on customer value analysis and measurement, framing customer value management as one of the main antecedents of the company value-creation process. The paper builds on three main pillars. First, the paper highlights the critical role of customer value in business-to-business markets, focusing on the links between the company’s ...
BUSACCA, BRUNO GIUSEPPE, ANCARANI, FABIO GUIDO, COSTABILE, MICHELE   +2 more
openaire   +3 more sources

Valuing customers

BT Technology Journal, 2005
This paper considers the metric of customer lifetime value as a way of placing an expected future value on a company's customers. This approach looks at the fundamental contribution a customer makes to a company's profits. The basic concept is useful in its own right, but it also allows an analogue between a customer and the equity of the company to be
D. Collings, N. Baxter
openaire   +1 more source

Customer Lifetime Value

2002
In diesem Beitrag wird zunachst der Begriff Customer Lifetime Value (CLV) erlautert. Anschliesend wird seine Berechnung anhand von einfachen Zahlenbeispielen erklart. Diese Beispiele zeigen auch die Schwierigkeit auf, will man in der Praxis einzelne Kunden oder Kundensegmente anhand dieses Wertes beurteilen.
Gierl, Heribert, Koncz, Julia
openaire   +1 more source

Valuing Customers

Journal of Marketing Research, 2003
It is increasingly apparent that the financial value of a firm depends on off-balance-sheet intangible assets. In this article, the authors focus on the most critical aspect of a firm: its customers. Specifically, they demonstrate how valuing customers makes it feasible to value firms, including high growth firms with negative earnings.
Sunil Gupta, Donald R. Lehmann, Jennifer Ames Stuart   +2 more
openaire   +1 more source

Customer Value Creation

2019
The concept customer value has many meanings (Woodall 2003), but, from a marketing theory, two dominate: customer value refers to customers’ perceptions of what they receive and in return for what they sacrifice (Zeithaml 1988). The creation of customer value has long been recognized as a central concept in marketing (Woodruff 1997)
openaire   +2 more sources

Dynamics of customer segments: A predictor of customer lifetime value

Expert Systems with Applications, 2021
Abstract Most studies in the literature have focused on past behavior of customers to measure customer lifetime value, however, the rapid developments of technology and products make new conditions that cannot be predicted by past records anymore. In the era of new media and social networks, customers’ needs and expectations change fast which lead to
Abdolreza Mosaddegh, Amir Albadvi, Mohammad Mehdi Sepehri, Babak Teimourpour   +3 more
openaire   +1 more source

Customer Lifetime Value Measurement

Management Science, 2008
The measurement of customer lifetime value is important because it is used as a metric in evaluating decisions in the context of customer relationship management. For a firm, it is important to form some expectations as to the lifetime value of each customer at the time a customer starts doing business with the firm, and at each purchase by the ...
Sharad Borle, Siddharth S. Singh, Dipak C. Jain   +2 more
openaire   +2 more sources