Results 91 to 100 of about 615,808 (305)

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

open access: yesFEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai   +2 more
wiley   +1 more source

Dense forests and Danzer sets [PDF]

open access: yes, 2014
A set $Y\subseteq\mathbb{R}^d$ that intersects every convex set of volume $1$ is called a Danzer set. It is not known whether there are Danzer sets in $\mathbb{R}^d$ with growth rate $O(T^d)$.
Solomon, Yaar, Weiss, Barak
core  

Aree archeologiche semi abbandonate, vuoti urbani e nuove iniziative di recupero

open access: yesArcheomatica, 2013
Un viaggio attraverso il progetto per la valorizzazione del patrimonio archeologico e artistico dell'area "Ad Duas Lauros" a Roma. In Cut: valorizzare il passato attraverso il presente.
Antonino Saggio, Denise Franzè
doaj  

Long-lasting intense cut-off lows to become more frequent in the Northern Hemisphere

open access: yesCommunications Earth & Environment
Cut-off Lows are slow-moving mid-latitude storms that are detached from the main westerly flow and are often harbingers of heavy and persistent rainfall.
Aditya N. Mishra   +5 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Validating Journal Cancellation Decisions in the Sciences: A Report Card

open access: yesIssues in Science and Technology Librarianship, 1998
Few libraries have remained unaffected by the serials pricing crisis of the past several years. The University of California, Santa Barbara (UCSB) Library has conducted five serials cancellations projects since 1987 -- 1987, 1989, 1991, 1994, and 1996 ...
Andrea L. (Andrea Louise) Duda   +1 more
doaj   +1 more source

A Stochastic Mixed Integer Programming Framework for Underground Mining Production Scheduling Optimization Considering Grade Uncertainty

open access: yesIEEE Access, 2020
Conventional mine planning approaches use an estimated orebody model as input to generate optimal production schedules. The smoothing effect of some geostatistical estimation methods cause most of the mine plans and production forecasts to be unrealistic
Shuwei Huang   +4 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Pattern Equivariant Cohomology and Theorems of Kesten and Oren

open access: yes, 2014
In 1966 Harry Kesten settled the Erd\H os-Sz\"usz conjecture on the local discrepancy of irrational rotations. His proof made heavy use of continued fractions and Diophantine analysis.
Kelly, Michael, Sadun, Lorenzo
core   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

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