Results 141 to 150 of about 4,889,471 (293)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

How to choose cut-off points: statistical and clinical perspectives

Korean Journal of Anesthesiology
Continuous variables are often dichotomized or categorized in clinical research to improve interpretability or to align with clinical thresholds. However, arbitrary or poorly justified cut-off points can cause substantial information loss, reduced statistical power, and potentially misleading conclusions.
Boohwi, Hong, Chahyun, Oh, Sang Gyu, Kwak   +2 more
openaire   +2 more sources

Creating cut-off points for the “Use of EBP” measure.

Creating cut-off points for the “Use of EBP” measure.
Kit Yat Leung (18120995), Fadi M. Al Zoubi (18120989), Shirley P. C. Ngai (7918727), Arnold Y. L. Wong (8615142), André Bussières (3144147), Aliki Thomas (3582098), Sharon M. H. Tsang (11725565), Yui Yin Ng (18120998), Ka Chun Lau (18121001), Hoi Wai Chan (18120992)   +9 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Utility of the brief Patient Health Questionnaire-2 and Generalized Anxiety Disorder-2 screeners for depression and generalized anxiety symptom identification in people with human immunodeficiency virus

HIV Research & Clinical Practice
Background Despite recommendations for routine mental health screening in human immunodeficiency virus (HIV) care settings, screening uptake remains low.
Grace Y. Lee, Maria C. Latimer, Sharon M. Kelly, Tarfa Verinumbe, Tracy Agee, Heidi Hutton, Catherine Lesko, Joyce Jones, Sheree Schwartz, Jeffrey Hsu, Oluwaseun Falade-Nwulia   +10 more
doaj   +1 more source

Determination of cut-off points for the Move4 accelerometer in children aged 8-13 years. [PDF]

BMC Sports Sci Med Rehabil, 2023
Beck F, Marzi I, Eisenreich A, Seemüller S, Tristram C, Reimers AK.   +5 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Somatic measurements and their use in establishing reference values

Biomedical Human Kinetics, 2012
Stupnicki Romuald
doaj   +1 more source

Cut-off points for low-deprivations and high-deprivations on input domains.

, 2013
Cut-off points for low-deprivations and high-deprivations on input domains.
Ronan A. Lyons (193419), Sinead Brophy (40627), Shang-Ming Zhou (293855), Mike B. Gravenor (243397)   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source