Results 81 to 90 of about 1,376,539 (213)
Optimum Design of Effective Parameters for Orthotropic Plates with Polygonal Cut-Out
Latin American Journal of Solids and StructuresThis paper investigates the effect of different parameters on stress analysis of infinite orthotropic plates with central polygonal cutout using gray wolf optimization algorithm.
Mohammad Jafari +1 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Dynamic response of the micro-perforated crab beam used in MEMS vibratory gyroscope device
Vietnam Journal of MechanicsThis paper presents a study on the dynamic response of the micro-beams with the crab shape and cut-out holes on the whole operating faces of the beam to create the micro-perforated beam by using FEM simulation software.
Vu Van The
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Comparison of Cut Out Transmission Variations on a 10x10 cm2 Applicator for Linac Electron Beam
Jurnal Fisika FluxRadiotherapy has provisions for providing radiation doses for patient therapy, as giving the minimum possible dose to healthy tissue and giving the maximum possible dose to cancer.
Alisya Oktafianingrum +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Effects of Elastic Couplings in a Compressed Plate Element with Cut-Out. [PDF]
Materials (Basel), 2022 Falkowicz K, Samborski S, Valvo PS.
europepmc +1 more source