Results 101 to 110 of about 1,473,799 (245)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Ivy Leaves, 1983-1984

open access: yes, 1984
The 1984 edition of the Anderson College journal of art and literature, Ivy Leaves. The names of the known editors for this issue of Ivy Leaves were Karen Buchanan, Leslie Allen, John Gettys, Cathy Grant, Marty Isom, Wendy Jones, Julie Poole, Charlene ...
Ivy Leaves Editorial Staff,
core  

Ivy Leaves, 2006

open access: yes, 2006
The 2006 edition of the Anderson University journal of art and literature, Ivy Leaves. The names of the known editors for this issue of Ivy Leaves were Jill Ayers, Cassie Kolasky, Maghan Lusk, Ashley McAdams, Jess Sopolosky, Danielle Webb, Kristy ...
Ivy Leaves Editorial Staff,
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Ivy Leaves, 1972-1973

open access: yes, 1973
The 1973 edition of the Anderson College journal of art and literature, Ivy Leaves. The names of the known editors for this issue of Ivy Leaves were Doug Davison, Glenda Alexander, Linda Buchmiller, Linda Davis, Walter Durst, Linda Edwards, Phil Franks ...
Ivy Leaves Editorial Staff,
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Ivy Leaves, 2004-2005

open access: yes, 2005
The 2005 edition of the Anderson College journal of art and literature, Ivy Leaves. The names of the known editors for this issue of Ivy Leaves were Joshua Burdette, Darcie Davis, Leanne Gray, Maghan Lush, Jessica Sopolosky, Marissa Sullivan, Sarah ...
Ivy Leaves Editorial Staff,
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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