Results 151 to 160 of about 8,885,199 (261)
, 1974 cut vThigh rubbers cut off at ankles in spring time when tops become worn.DNE-cit -1974 WK JH 5/76Used I and SupUsed I3Not Usedcut off (the linnet/twine), cut out (a young seal), cut-tail, cut-throat(er), cut-off, cut pole, cutwater, cut tails, cut ...
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Age-adjusted D-dimer cut-off levels to rule out venous thromboembolism in COVID-19 patients. [PDF]
Thromb Res, 2020 Roncon L, Zuin M, Zonzin P.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2015 a Data presented as % (patients with severe pneumococcal pneumonia and DNA density ≥ cut-off/all patients with severe pneumococcal pneumonia).b Data presented as % (patients with severe pneumococcal pneumonia and DNA density ≥ cut-off /all patients with ...
Simon Athlin (813150) +7 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Egyptian Journal of Internal MedicineBackground The optimal cut-off level of lactoferrin in ascitic fluid is debatable for identification of spontaneous bacterial peritonitis (SBP). This study aimed to detect the cut-off level of lactoferrin in ascitic fluid and its role in the diagnosis of
Walid Abdelrehim +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Gynecology Obstetrics & Reproductive Medicine, 2013 OBJECTIVE: To investigate whether the 3rd hour value of 100 g oral glucose tolerance test (OGTT) can be ignored when diagnosing gestational diabetes. STUDY DESIGN: During the first 8 months of 2010, 6909 patients between 24 and 28 weeks’ of gestation ...
Mehmet Metin Altay +7 more
doaj