Results 61 to 70 of about 127,725 (216)
Results in Earth SciencesSlope stability assessment of different road cut slopes has been conducted along the National Highway in Garhwal Himalaya, Uttarakhand (NH-34, NH-134, NH-7, NH-107 and a state highway from Dharasu to Tilwara).
Biswajit Bera, Soumik Saha
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Risk-based stabilization planning for soil cut slopes [PDF]
Natural Hazards and Earth System Sciences, 2009 Risk-based slope stabilization planning integrates the failure probability and the failure consequence systematically and shows promise for use in the practice.
D. Li, L. Zhang, C. Zhou, W. Lu
doaj
A participatory approach to determine the use of road cut slope design guidelines in Nepal to lessen landslides [PDF]
Natural Hazards and Earth System SciencesRoad cut slope failures are a type of landslide process and are extensive across the road network of Nepal. In response to the pressing need for improved road cut slope design guidelines to help prevent these failures, this study employs a participatory ...
E. B. Robson, B. K. Dahal, D. G. Toll
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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New risk assessment methodology for coal mine excavated slopes
International Journal of Mining Science and Technology, 2018 This paper presents a new risk assessment methodology for coal mine excavated slopes. This new empirical-statistical slope stability assessment methodology (SSAM) is intended for use by geotechnical engineers at both the design review and operational ...
Alison McQuillan +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
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Rock mass assessment along the right bank of river Sutlej, Luhri, Himachal Pradesh, India
Geomatics, Natural Hazards & Risk, 2015 The study involves the characterization of rock mass along the right bank of river Sutlej, Luhri, Himachal Pradesh. This road connects to several important locations and therefore blockage due to slope failure may cause several problems.
P.K. Singh +2 more
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Monitoring of the Surface Displacements of the Final Slope at Mt.Buko
Journal of MMIJ, 2018 This study examines reliable methods to monitor and manage the stability of a limestone rock slope. The surface displacement of the rock slope of Mt. Buko has been measured over the past 20 years, employing several tools and methods including automated ...
Tsurugi NAKATANI +5 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source