Results 131 to 140 of about 2,501,512 (375)

Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi-institutional retrospective study [PDF]

, 2016
Background: Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects.
Bonadies, CARLO ALBERTO, Bucher, S, Cabula, C, Campana, Lg, Curatolo, Pietro, Grilz, G, Guida, M, Rossi, C. r., Rotunno, Roberta, Santoriello, Andrea, Solari, N, Strippoli, S, Valpione, S   +12 more
core   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Effects of cutaneous administration of an over-the-counter menthol cream during temperate-water immersion for exercise-induced hyperthermia in men. [PDF]

Front Physiol, 2023
Wang G, Hurr C.
europepmc   +1 more source

Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts

Scientific Reports, 2016
Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem ...
Li-juan Hu, Juan Wang, Xin Zhou, Zehuan Xiong, Jiajia Zhao, Ran Yu, Fang Huang, Handong Zhang, Lili Chen   +8 more
semanticscholar   +1 more source

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Pupal surveys for Aedes aegypti surveillance and potential targeted control in residential areas of Mérida, México.

, 2008
A mosquito larval-pupal survey was conducted in 1,160 households of the Mexican city of Mérida during the rainy season of 2003 to determine their differential productivity for Aedes aegypti.
Che-Medoza, Azael, Coleman, Paul G, Davies, Clive R, Dzul-Manzanilla, Felipe, Manrique-Saide, Pablo, Rebollar-Tellez, Eduardo, Zapata-Peniche, Adan   +6 more
core   +1 more source

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action [PDF]

, 2004
Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to ...
Caro, I., Dedrick, R., Dummer, W., Joshi, A., Jullien, D., Langley, RGB, Natta, P., Prinz, Jörg Christoph   +7 more
core   +1 more source

Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans

The Journal of Physiology, 2009
Reflex vasoconstriction (VC) is attenuated in aged skin resulting in greater skin blood flow and heat loss during cold exposure. We hypothesized that adrenergic function is compromised due to depletion of tetrahydrobiopterin (BH4), an essential cofactor required for catecholamine synthesis, and therefore local BH4 supplementation would functionally ...
Lacy A. Holowatz, James A. Lang, W. Larry Kenney   +2 more
openaire   +4 more sources

A Non‐Coding Oligonucleotide Recruits Cutaneous CD11b+ Cells that Inhibit Thelper Responses and Promote Tregs

Advanced Science
Skin‐resident antigen‐presenting cells (APC) play an important role in maintaining peripheral tolerance via immune checkpoint proteins and induction of T regulatory cells (Tregs).
Kahkashan Kamal, Elina Richardsdotter‐Andersson, Aleksandra Dondalska, Marie Wahren‐Herlenius, Anna‐Lena Spetz   +4 more
doaj   +1 more source