Objective The pharmacodynamic effects of litifilimab on type I interferon (IFN) response and correlations with clinical outcomes were investigated in systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). Methods Participants from Part A (SLE) or Part B (CLE with/without SLE) of the randomized phase II LILAC trial who received ...
Richard Furie+8 more
wiley +1 more source
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza+26 more
wiley +1 more source
Medications, epilepsy and climate change: Added layers of complexity
Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi+2 more
wiley +1 more source
Eosinophilic cellulitis (Wells' syndrome) as a cutaneous reaction to the administration of adalimumab [PDF]
Panagiota Boura
openalex +1 more source
Inadequate and delayed characterization of cutaneous reactions for US Food and Drug Administration–approved oncologic drugs from 2011–2020 leading to medication discontinuation [PDF]
Jason Yang+5 more
openalex +1 more source
Exogenous melatonin administration modifies cutaneous vasoconstrictor response to whole body skin cooling in humans [PDF]
Ken Aoki+6 more
openalex +1 more source
Multiple Mesenchymal Stem Cell Derived Extracellular Vesicle Administration Accelerates Healing and Ameliorates Tissue Scarring Compared with Single Application in Full Thickness Cutaneous Wounds [PDF]
Hasti Tashak Golroudbari+10 more
openalex +1 more source
Evaluation of neoadjuvant prednisone administration and surgical excision in treatment of cutaneous mast cell tumors in dogs [PDF]
Rebecca M. Stanclift, Stephen D. Gilson
openalex +1 more source
Clinical Images: Subcutaneous panniculitis‐like T cell lymphoma
Arthritis &Rheumatology, EarlyView.
S Chambers, CN Myrdal, VP Werth
wiley +1 more source
Engineering antibodies with cancer‐associated binding sites
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian+4 more
wiley +1 more source