Results 211 to 220 of about 206,699 (375)

Ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicology of the subfamily Gomphrenoideae (Amaranthaceae): A comprehensive review

open access: yesChemistry &Biodiversity, Accepted Article.
The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its promising ...
Dayanna Isabel Araque Gelves   +3 more
wiley   +1 more source

Probability of Target Attainment Analyses to Inform Ceftolozane/Tazobactam Dosing Regimens for Patients With Hospital‐Acquired or Ventilator‐Associated Bacterial Pneumonia and End‐Stage Renal Disease Receiving Intermittent Hemodialysis

open access: yesThe Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 166-171, February 2023., 2023
Abstract ASPECT‐NP, a phase 3 trial of ceftolozane/tazobactam in hospital‐acquired/ventilator‐associated bacterial pneumonia (HABP/VABP), excluded patients with end‐stage renal disease (ESRD). A modeling/simulation approach was undertaken to inform optimal dosing in this population, using previously developed ceftolozane and tazobactam population ...
Hwa‐Ping Feng   +7 more
wiley   +1 more source

Osteohistological characterization of notosuchian osteoderms: Evidence for an overlying thick leathery layer of skin

open access: yesJournal of Morphology, Volume 284, Issue 1, January 2023., 2023
The perpendicular insertion of Sharpey's fibers in the external cortex suggests the presence of a thick leathery skin layer overlying notosuchian osteoderms. Although intramembranous ossification is the main process involved in the development of crocodyliform osteoderms, we reported a case of metaplastic development.
Mariana Valéria de Araújo Sena   +12 more
wiley   +1 more source

Optimizing Brentuximab Vedotin Dosing in Pediatric Patients with Advanced Hodgkin Lymphoma: A Population Pharmacokinetic and Exposure‐Response Analysis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pediatric patients with advanced‐stage newly diagnosed Hodgkin lymphoma (HL) were treated with brentuximab vedotin (BV) combined with adriamycin, vinblastine, and dacarbazine (A + AVD). Weight‐based BV dosing is employed in adult patients, while both body weight‐ and body surface area (BSA)‐based dosing are used in pediatric patients.
Xiaofei Zhou   +4 more
wiley   +1 more source

Nuclear localisation sequences of chloride intracellular channels 1 and 4 facilitate nuclear import via interactions with import mediator importin‐α: An empirical and theoretical perspective

open access: yesJournal of Molecular Recognition, Volume 36, Issue 2, February 2023., 2023
Structural and CLIC unclear localisation sequence binding differences between mouse Importin α1 (grey) and human Importin α1 (green) show conformational and sequence differences between the two structures. Nonetheless, the major binding pocket of Impα for interacting with cargo NLSs is highly conserved. Abstract Chloride intracellular channel proteins (
Olga Færch   +3 more
wiley   +1 more source

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma

open access: yes
Cancer Communications, EarlyView.
Katia Mariniello   +37 more
wiley   +1 more source

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