Streamlining Vorinostat Synthesis: A Chemoenzymatic Continuous Flow Approach
A chemoenzymatic protocol for the synthesis of histone deacetylase inhibitor vorinostat has been established. Immobilized lipase from C. antarctica (imm‐CaLB) allowed the functionalization of suberanoyl acid 1 and further conversion to vorinostat via ion‐exchange resin treatment.
Francesca Annunziata+6 more
wiley +1 more source
Painful skin ulcers in psoriasis patients after taking methotrexate-containing traditional Chinese medicine: a retrospective case series. [PDF]
Zheng Y, Dubai Y, Wang R, Luo S.
europepmc +1 more source
Poster 235: Cutaneous Administration of Local Anesthetic for Spine Injection Procedures: A Prospective, Randomized Controlled Trial of Patient Preferred Method [PDF]
Rishi R. Bakshi, Matthew Smuck
openalex +1 more source
Neuronal surface and intracellular antibody testing in patients with long‐term epilepsy
Abstract Objective We aimed to investigate the frequency of neuronal surface and intracellular antibodies in individuals with long‐term epilepsy and the associated clinical and laboratory characteristics. Methods We tested sera from 223 patients with epilepsy without signs of autoimmune encephalitis and 12 patients with epilepsy and a subacute onset of
Nancy Watanabe+9 more
wiley +1 more source
Cutaneous Allodynia of the Withers in Cattle: An Experimental In Vivo Neuroanatomical Preliminary Investigation of the Dichotomizing Sensory Neurons Projecting into the Reticulum and Skin of the Withers-A Case Study on Two Calves. [PDF]
Chiocchetti R+8 more
europepmc +1 more source
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li+15 more
wiley +1 more source
A Brief Overview of Uveal Melanoma Treatment Methods with a Focus on the Latest Advances. [PDF]
Wdowiak K+4 more
europepmc +1 more source