Results 291 to 300 of about 2,574,537 (354)

Extracellular vesicle‐based vaccines and immunotherapeutics for treatment of cancer

Interdisciplinary Medicine, EarlyView.
This review highlights the innovative value of extracellular vesicles (EVs) as cancer vaccines and immunotherapy carriers. EVs have natural advantages such as low immunogenicity, high biocompatibility, stability, and precise targeting, enabling efficient delivery of tumor antigens (e.g., HER2, AFP) and immune stimulants (e.g., TLR ligands, cytokines ...
Lejia Tan, Haonan Xing, Fang Fang, Yuanyu Huang, Mei Lu   +4 more
wiley   +1 more source

Unfolding the risk: a pilot study of airborne contamination in the operating room during total joint arthroplasty. [PDF]

J Orthop Surg Res
Ibrahim DA, Frey A, Hancock JU, Budny BG, Adams JL, Tomlinson B, Shaw LN, Lyons ST.   +7 more
europepmc   +1 more source

Freeze‐resistant, conductive semi‐interpenetrating network hydrogels enable oxidative stress regulation and enhanced wound healing

Interdisciplinary Medicine, EarlyView.
A multifunctional SFMA9/PF1 semi‐interpenetrating hydrogel with excellent conductivity, antioxidant activity, and freeze resistance effectively regulates the wound microenvironment, reduces oxidative stress and inflammation, promotes angiogenesis, and accelerates full‐thickness skin regeneration.
Xiaomin Sun, Yanqin Yu, Xinyuan He, Kaiyi Tang, Lijing Teng, Tianbao Qian, Zhu Zeng, Zuquan Hu   +7 more
wiley   +1 more source

Remarkable Prolongation of Irreversible APTT and Non‐Significant Hemorrhage: A Rare High Titer of FVIII Inhibitor Case Report and Literature Review

Journal of Clinical Laboratory Analysis, EarlyView.
Patient with a bladder cancer history presented was diagnosed with Acquired hemophilia A (AHA) according to imaging findings and laboratory tests. The parameters returned to normal after treatment of methylprednisolone and cyclophosphamide. With the recurrence of AHA, the patient was finally confirmed to have liver metastases.
Ke‐Han Zhang, Song‐Song Lu, Pei‐Liang Gao, Xue‐Ying Fu, Gui‐Ying Dong   +4 more
wiley   +1 more source

Evaluation of Discoidin domain receptor 1 (DDR1) in junctional epithelial permeability and wound healing

Journal of Periodontology, EarlyView.
Abstract Background Epithelium is the periodontal first line of defense against microbes. Discoidin domain receptor 1 (DDR1) is a collagen receptor expressed in epithelium. Ddr1 knockout (Ddr1−/−) mice develop periodontitis‐like defects, including junctional epithelium (JE) downgrowth, bacterial invasion, and alveolar bone loss.
Christina Zachariadou, Anuja Doshi, Dimitris N. Tatakis, Brian L. Foster   +3 more
wiley   +1 more source

Vedolizumab for extraintestinal manifestations in pediatric inflammatory bowel disease: Results from the VedoKids study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Extraintestinal manifestations (EIMs) manifest in 6%‐47% of patients with inflammatory bowel disease (IBD). Here, we characterize the course of EIMs in pediatric patients receiving vedolizumab included in the VedoKids cohort study. This was a subgroup analysis of the pediatric VedoKids cohort, a multicenter, prospective study of children (aged
Giulia D'Arcangelo, Dan Turner, Oren Ledder, Esther Orlanski‐Meyer, Efrat Broide, Maya Granot, Manar Matar, Seamus Hussey, Anat Yerushalmy‐Feler, Christoph Norden, Erasmo Miele, Marina Aloi   +11 more
wiley   +1 more source

Clinical, manometric, genetic, and histologic associations in pediatric intestinal pseudo‐obstruction: A case series

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Sharon Wolfson, Myra Butrviengpunt, Naomi Tjaden, Alain J. Benitez, Archana S. Kota, Jennifer Webster, Prasanna Kapavarapu, Hayat Mousa, Robert O. Heuckeroth   +8 more
wiley   +1 more source

Drug Hypersensitivity: A Correlation Study From Histopathology to Clinic

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Drug hypersensitivity (DH) can present with varied clinical and pathological manifestations that may mislead the referring physician. Available data regarding the concordance between pathological diagnosis and clinical findings in DH are scarce.
Olivier Philip, Morgane Stichelbout, Marie Verhasselt‐Crinquette, Baptiste Mille, Delphine Staumont‐Sallé, Frédéric Dezoteux   +5 more
wiley   +1 more source

Applicability of Novel Laser Scanning Microscopy Techniques in Demonstrating Characteristic Features of Porokeratosis: In Vivo and Ex Vivo Investigation

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Porokeratoses represent a group of keratinization disorders characterized histopathologically by the presence of a cornoid lamella. The recognition of porokeratosis as a genodermatosis, along with its association with increased risk of skin cancer, underscores the importance of accurate and timely diagnosis.
Rahime Inci, Noora Neittaanmäki, Jeemol James, Marica B. Ericson, Sirkku Peltonen, Despoina Kantere   +5 more
wiley   +1 more source

Hell's Itch: An Acute Reaction to Sunburn Exposure

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a neurocutaneous dysesthesia following sunburn that is underreported in scientific literature despite considerable discussion online. ‘Hell's itch’ describes an acute, uncontrollable itch with intense stabbing pain several days post‐sunburn and often follows an inciting event such as water exposure.
Colin Kelly, Connor Stonesifer, Brian W. Morrison   +2 more
wiley   +1 more source