Results 71 to 80 of about 39,931 (290)

GPA-Tree: Statistical Approach for Functional-Annotation-Tree-Guided Prioritization of GWAS Results [PDF]

arXiv, 2021
Motivation: In spite of great success of genome-wide association studies (GWAS), multiple challenges still remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), each with small or moderate effect sizes. Second, our understanding of the functional mechanisms through which genetic variants are associated ...
arxiv  

Cutaneous Force Feedback as a Sensory Subtraction Technique in Haptics [PDF]

D. Prattichizzo, C. Pacchierotti, G. Rosati. Cutaneous force feedback as a sensory subtraction technique in haptics. IEEE Transactions on Haptics, 5(4):289-300, 2012, 2011
A novel sensory substitution technique is presented. Kinesthetic and cutaneous force feedback are substituted by cutaneous feedback (CF) only, provided by two wearable devices able to apply forces to the index finger and the thumb, while holding a handle during a teleoperation task.
arxiv   +1 more source

Would You Recognize Lupus? [PDF]

, 2018
Systemic Lupus Erythematosus, or SLE, is a chronic autoimmune disease which significantly affects various organs of the body and the oral cavity. According to various studies, SLE can cause an increased risk of periodontitis, fungal infections, and ...
Brown, Barbara, Simms, Maegan, Smith, Sydney C   +2 more
core   +1 more source

Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. [PDF]

, 2017
Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical database from the largest multicenter cohort of African American SSc patients assembled
Boin, Francesco, Carns, Mary, Chung, Lorinda, Criswell, Lindsey A, Derk, Chris T, Domsic, Robyn T, Gladue, Heather, Goldberg, Avram, Gordon, Jessica K, Gourh, Pravitt, Hsu, Vivien, Jan, Reem, Kastner, Daniel L, Khanna, Dinesh, Mayes, Maureen D, Medsger, Thomas A, Morgan, Nadia D, Ramos, Paula S, Remmers, Elaine F, Saketkoo, Lesley A, Schiopu, Elena, Shah, Ami A, Shanmugam, Victoria K, Silver, Richard M, Steen, Virginia D, Trojanowski, Marcin A, Valenzuela, Antonia, Varga, John, Wigley, Fredrick M   +28 more
core   +1 more source

Differentiating reactive and neoplastic gamma‐delta (γδ) T‐cell expansions in the peripheral blood and bone marrow

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract The clinical and immunophenotypic attributes of reactive γδ T‐cell expansions are less well characterized than their malignant counterparts, which can pose diagnostic challenges. This study aims to investigate the characteristics and long‐term clinical outcomes of reactive γδ T‐cell expansions.
Hamza Tariq, Zubair Ilyas, Lucy Fu, Yijie Liu, Qing Ching Chen, Kristy Wolniak, Yi‐Hua Chen   +6 more
wiley   +1 more source

High Expression of CDK1 and NDC80 Predicts Poor Prognosis of Bladder Cancer [PDF]

arXiv, 2021
Background: Bladder cancer is the 10th most common cancer worldwide, and its prevalence is increasing, especially in developing countries. Objective: In the present study, we employed gene expression profiles from the GSE163209 data set in the GEO database to identify potential molecular and genetic markers in BC patients.
arxiv  

multi-GPA-Tree: Statistical Approach for Pleiotropy Informed and Functional Annotation Tree Guided Prioritization of GWAS Results [PDF]

arXiv, 2023
Genome-wide association studies (GWAS) have successfully identified over two hundred thousand genotype-trait associations. Yet some challenges remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), most with small or moderate effect sizes, making them difficult to detect. Second, many complex traits share a
arxiv  

Subacute cutaneous lupus erythematosus starting as linear lupus erythematosus [PDF]

International Journal of Dermatology, 2015
AbstractBackgroundCutaneous lupus in childhood is usually associated with systemic lupus erythematosus (LE). Linear cutaneous LE (LCLE) is an unusual presentation mostly seen in children and young adults.MethodsWe report a rare case of cutaneous subacute LE with a segmentary pattern following the lines of Blaschko in an 18‐month‐old girl with a 2‐month
José C. Pascual, Isabel Betlloch, Maria Leiva-Salinas, Laura Frances, Irene Marin   +4 more
openaire   +4 more sources

Skin microbiome engineering: Challenges and opportunities in skin diseases treatment

iMetaOmics, EarlyView.
The skin microbiome plays a crucial role in skin health, influencing barrier integrity, immune responses, and disease susceptibility. Various interventions can reshape the microbiome, broadly categorized into targeted and untargeted approaches. Targeted strategies, such as phage therapy, engineered bacteria, and phage lysins, selectively modulate ...
Yiang Lyu, Juntao Shen, You Che, Lei Dai
wiley   +1 more source

Systemic Lupus Erythematosus Presented with Bilateral Orbital Edema and Negative Serology

Case Reports in Rheumatology, 2019
Isolated bilateral periorbital edema with negative serology is an extremely rare presentation of cutaneous lupus erythematosus that may lead to eyelid scarring, infection, or even corneal involvement.
Manal Al-Khaldi, Manal Alsabbagh
doaj   +1 more source