Results 291 to 300 of about 101,476 (335)

Effective Use of Topical Ketamine in Managing Acute Post‐Operative Pain Following Fournier's Gangrene Surgery: A Case Report

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Topical ketamine effectively reduces acute postoperative pain following Fournier's gangrene surgery, allowing for opioid reduction and enhancing patient comfort during wound care. Its use provides an alternative to systemic opioids, minimizing side effects and dependency risks. Further research is needed to optimize dosing and confirm outcomes.
Aariya Srinivasan, Madeline Dow, Renata Barbosa Dos Santos, Sabry Ayad   +3 more
wiley   +1 more source

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap, Olivier Rixe, Capucine Baldini, Ursa Brown‐Glaberman, Sergey Efuni, David S. Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H. Shiue, Yi Liu, Matthew W. Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam   +16 more
wiley   +1 more source

Immune Checkpoint Inhibitor‐Related Dysautonomia in Merkel Cell Carcinoma: A Case Report

Cancer Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block inhibitory pathways that cancer cells exploit to suppress T‐cell activation. Although immune‐related adverse events (irAEs) linked to ICI therapy are well documented and encompass dermatologic, endocrine, gastrointestinal, hepatic, and neurologic systems, ICI ...
Nidhi Kuchimanchi, Sai Gajula, Elizabeth M. Gaughan, Russell G. Witt   +3 more
wiley   +1 more source

CD70: An emerging target for integrated cancer diagnosis and therapy

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
CD70 is aberrantly overexpressed in diverse tumours with limited normal tissue expression, making it a compelling diagnostic and therapeutic target. Immuno‐PET/CT facilitates tumour detection, staging, and treatment monitoring. Multiple CD70‐targeted therapies are under early evaluation. Rational combination strategies are emerging to enhance antitumor
Jiatao Hu, Jinxin Li, Bo Yang, Siyi Wang, Yi Bao, Yiren Yang, Kun Qiao, Fei Guo, Xinxin Gan, Linhui Wang   +9 more
wiley   +1 more source

A Case Series and Literature Review of Angiosarcoma With Malignant Effusion—A Challenging Cytologic Diagnosis With Dire Prognostic Implications

Diagnostic Cytopathology, Volume 53, Issue 7, Page E119-E126, July 2025.
ABSTRACT Angiosarcoma with malignant effusion is an uncommon yet clinically aggressive presentation, which poses as a diagnostic pitfall with its overlapping cytomorphologic features with metastatic adenocarcinoma. In this article, two cases reported in the literature were reviewed for cytology, immunocytochemistry, and clinical course.
Jamie C. Y. Lam, Iris Y. H. Liu, Joanna K. M. Ng, Joshua J. X. Li   +3 more
wiley   +1 more source

A striking case of cutaneous adult T-cell leukemia/lymphoma mimicking subacute cutaneous lupus erythematosus. [PDF]

JAAD Case Rep
Alicea DS, Muddasani S, Occidental M, Amin B, McLellan BN, Wu B.   +5 more
europepmc   +1 more source

Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from Indonesia. [PDF]

BMC Res Notes
Harahap AS, Santoso I, Charles S, Mulansari NA, Ham MF.   +4 more
europepmc   +1 more source

How to treat primary cutaneous B cell lymphoma - Results from a monocentric cohort study on 98 patients. [PDF]

J Dtsch Dermatol Ges
Cankaya R, Kleiner PL, Hilke FJ, Moritz R, Eigentler T, Schlaak M, Dobos G.   +6 more
europepmc   +1 more source

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Cutaneous T cell lymphoma

Nature Reviews Disease Primers, 2021
Primary cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphomas that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. CTCL subtypes demonstrate a variety of clinical, histological, and molecular features, and can follow an indolent or a very aggressive course.
Dummer, Reinhard, Vermeer, Maarten H, Scarisbrick, Julia J, Kim, Youn H, Stonesifer, Connor, Tensen, Cornelis P, Geskin, Larisa J, Quaglino, Pietro, Ramelyte, Egle   +8 more
openaire   +4 more sources

Cutaneous lymphomas

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2007
SummaryCutaneous lymphomas are rare skin diseases. They must be differentiated from secondary skin infiltrates by primary nodal lymphomas. Primary cutaneous lymphomas can be classified into B‐ and T‐cell lymphomas and hematodermic neoplasms; they usually possess a favorable prognosis and run a chronic course. Treatment is dependent on stage.
Reinhard, Dummer, Rudolf, Stadler, Wolfram, Sterry   +2 more
openaire   +4 more sources