Results 151 to 160 of about 25,809 (268)

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

open access: yesJournal of Diabetes Investigation, EarlyView.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan   +4 more
wiley   +1 more source

Male genital lichen sclerosus

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Male genital lichen sclerosus is driven by chronic, occluded exposure of susceptible genital epithelium to urine, rather than infection or autoimmunity. This review synthesizes clinical, anatomical and molecular evidence showing how microincontinence and occlusion initiate inflammation, fibrosis and carcinogenesis, and explains the curative effect of ...
Georgios Kravvas   +3 more
wiley   +1 more source

Role of the tomato MARS1/ROUGH gene encoding a LYSINE‐SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation

open access: yesJournal of Integrative Plant Biology, EarlyView.
The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba   +14 more
wiley   +1 more source

ZmMS1 coordinates ROS homeostasis, lipid allocation, and male fertility for maize breeding applications

open access: yesJournal of Integrative Plant Biology, EarlyView.
The redox‐sensitive transcriptional repressor ZmMS1 coordinates reactive oxygen species homeostasis and lipid allocation for pollen exine and anther cuticle formation. Loss or precocious expression of ZmMS1 causes male sterility. Constitutive overexpression induces dwarfism and semi‐sterility. These findings enable flexible maize male‐sterility systems
Quancan Hou   +13 more
wiley   +1 more source

Differentiating Inflammatory Breast Cancer From Lactational Mastitis: A Diagnostic Challenge

open access: yesJournal of Midwifery &Women's Health, EarlyView.
Abstract Inflammatory breast cancer (IBC) is a rare but aggressive form of cancer; hence, early diagnosis is essential. Although predominantly occurring in older women, it can occur during pregnancy and lactation, making the diagnosis especially challenging.
Irena Zakarija‐Grković
wiley   +1 more source

Preimaginal development of Aedes aegypti L. (Diptera: Culicidae) in brackish water gives rise to adult mosquitoes with thicker cuticles and greater insecticide resistance

open access: yesMedical and Veterinary Entomology, EarlyView.
The principal arboviral vector Aedes aegypti can develop in coastal brackish water field habitats (0.5–15 g/L salt) with larvae possessing thicker cuticles and greater resistance to the larvicide Temephos. Females emerging from brackish water‐developing preimaginal stages are now shown to have thicker and remodelled leg and abdominal cuticles and ...
Kokila Sivabalakrishnan   +6 more
wiley   +1 more source

The roads most traveled: genetic convergence in plant repeated evolution

open access: yesNew Phytologist, EarlyView.
Observation of a genotype–phenotype association in a focal lineage (magnifying lens) provides a starting point for predicting homolog reuse during repeated trait evolution. This review suggests that the likelihood that mutations in homologous genes contribute to similar phenotypes in other lineages depends on both mutational effect stability (MES) and ...
James W. Satterlee
wiley   +1 more source

Chemical diversity of cuticular waxes in the honeysuckle family (Caprifoliaceae)

open access: yes
The above-ground organs of most land plants are covered by a hydrophobic cuticle, which limits non-stomatal water loss and protects against insect herbivores and pathogens. The cuticle consists of a cutin matrix associated with hydrocarbon-derived waxes.
Kelly, Madison
core  

Home - About - Disclaimer - Privacy