Results 21 to 30 of about 3,941 (260)

Experimental investigation of the rock cutting process and derivation of the 3D spatial distribution of the formation strength using in-cutter sensing

Journal of Petroleum Exploration and Production Technology, 2023
Recent advances in downhole measurements allow to accurately measure drilling forces at the drill bit, and estimate the evolution of the rock strength along the well profile. This paper presents an experimental methodology that allows to measure drilling
Alexis Koulidis, Gilles Pelfrene, Shehab Ahmed   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

An Energy Efficiency Tool Path Optimization Method Using a Discrete Energy Consumption Path Model

Machines, 2022
As the energy cost accounts for about one-third of the total manufacturing cost, there is great significance in evaluating and managing energy consumption in manufacturing processes.
Yicong Gao, Shanghua Mi, Hao Zheng, Qirui Wang, Zhe Wei   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Capabilities assessment for working bodies of rotary snowblowers through design and technological parameters study

Вестник СибАДИ, 2023
Introduction. At the initial stages of designing snow blower feeders, it is necessary to have relatively simple ratios on the basis of which one can judge their efficiency and their potential.
D. S. Aleshkov, P. A. Korchagin, I. A. Teterina, E. V. Khirianov   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Analytical method for calculating scallop height of helical toroidal cutter in five-axis milling [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2020
This paper proposed a method to determine the path scallop of toroidal cutter in five-axis milling during a complex surface machining. A mathematical algorithm was developed by taking into consideration the impact of the helical angle and inclination ...
Hendriko Hendriko
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

A solid-analytical-based model for extracting cutter-workpiece engagement in 5-axis flank machining

MATEC Web of Conferences, 2018
5-axis flank milling is applied extensively in aerospace, die-molds, and automotive industries because of high efficient material removal rate. Commercial CAM software can only simulate the tool path and collision at present, but cannot handle with ...
Li Dongdong, Zhang Weimin, Shang Tengfei, Gao Tianhong, Liu Shuo, Fleischer Jürgen   +5 more
doaj   +1 more source