Results 111 to 120 of about 327,426 (292)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Justification of Parameters of a Prismatic Device for Fertiliser Distribution Across the Width of the Sub-Blade Area of a Flat-Cutting Working Body

Acta Technologica Agriculturae
Subsurface application of mineral fertilisers is an effective agricultural technique that improves both the quantity and quality of cultivated crops. To ensure uniform distribution of granular mineral fertilisers across the width of a tillage working ...
Kuvaev Anton Nikolaevich, Derepaskin Alexey Ivanovich, Tokarev Ivan Vladimirovich, Polichshuk Yurij Vladimirovich, Binyukov Yurij Viktorovich, Ivanchenko Pavel Grigoryevich, Semibalamut Alexander Viktorovich   +6 more
doaj   +1 more source

A New Cutting Strategy to Reduce Plasticity Errors in Measuring Welding Residual Stress via the Contour Method

Journal of Manufacturing and Materials Processing
The Contour Method is a well-established destructive technique for determining cross-sectional maps of residual stress in manufactured metallic components. The validity of the technique is dependent on linear elastic relaxation of residual strains across
Sanjooram Paddea, Ruiyao Zhang, Xiaodong Hou, Fan Yang, Wenchao Dong, Shanping Lu, Peter John Bouchard, Shuyan Zhang   +7 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An ILP Solver for Multi-label MRFs with Connectivity Constraints

, 2017
Integer Linear Programming (ILP) formulations of Markov random fields (MRFs) models with global connectivity priors were investigated previously in computer vision, e.g., \cite{globalinter,globalconn}.
Ayed, Ismail Ben, Kendinibilir, Eric, Lodi, Andrea, Reinelt, Gerhard, Shen, Ruobing, Tramontani, Andrea   +5 more
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

弧齿锥齿轮齿面发生线切齿法探讨

Jixie chuandong, 2009
An arc in the plane that is tangent with the base cone of the spiral bevel gear,and absolutely rolling on the cone surface will form the surface of a spiral bevel bear with spherical involutes tooth form,a new precisely cutting way of the spiral bevel ...
张学成, 李春光, 李桂娇
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cutting plane method in decision analysis

, 2004
Several computational decision analysis approaches have been developed over a number of years for solving decision problems when vague and numerically imprecise information prevails. However, the evaluation phases in the DELTA method and similar methods often give rise to special bilinear programming problems, which are time-consuming to solve in an ...
Ding, Xiaosong, Al-Khayya, Faiz
openaire   +1 more source