Results 61 to 70 of about 327,426 (292)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Group Stable Matching Problem in Freight Pooling Service of Vehicle–Cargo Matching Platform

Systems
With the continuous advancement of the Internet and information technologies, the capacity for development and integration of vehicle and cargo resources has been significantly enhanced, driving the rapid emergence of vehicle–cargo matching platforms ...
Linlin Kong, Min Huang
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Analyzing orthogonal cutting process using SPH method by kinematic cutting tool

Comptes Rendus. Mécanique, 2020
In this paper, the orthogonal cutting process is studied using Smooth Particle Hydrodynamic (SPH) method by a kinematic rigid cutting tool and two work-piece material models: perfectly elastic-plastic (EPP) model and Johnson–Cook (JC) model.
Dehghani, Mohammad, Shafiei, Alireza, Abootorabi, Mohammad Mahdi   +2 more
doaj   +1 more source

An Adaptive Proximal Bundle Method with Inexact Oracles for a Class of Nonconvex and Nonsmooth Composite Optimization

Mathematics, 2021
In this paper, an adaptive proximal bundle method is proposed for a class of nonconvex and nonsmooth composite problems with inexact information. The composite problems are the sum of a finite convex function with inexact information and a nonconvex ...
Xiaoliang Wang, Liping Pang, Qi Wu, Mingkun Zhang   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Training linear ranking SVMs in linearithmic time using red-black trees

, 2011
We introduce an efficient method for training the linear ranking support vector machine. The method combines cutting plane optimization with red-black tree based approach to subgradient calculations, and has O(m*s+m*log(m)) time complexity, where m is ...
Antti Airola, Bayer, Bottou, Bradley, Burges, Chapelle, Chapelle, Cormen, Cortes, Cortes, Drucker, Franc, Freund, Fürnkranz, Hanley, Herbrich, Joachims, Joachims, Joachims, Joachims, Lewis, Liu, Pahikkala, Poggio, Provost, Smola, Tapio Pahikkala, Tapio Salakoski, Teo, Teo, Tsochantaridis, Waegeman, Williams   +32 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Discussing the Cutting Method of Skew Bevel Bear based on the Tooth Surface Generating Line

Jixie chuandong, 2020
The principle of tooth surface generating of skew bevel gear is analyzed about spherical involute， based on the theory that the line which in the plane that is tangent with the base cone of the skew bevel gear roll on the cone surface absolutely， a new ...
Baichao Wang, Xianting Lu, Litong Zhang, Zhenquan Xu, Xue Zhang   +4 more
doaj  

Direct method of hierarchical nonlinear optimization - reassessment after 30 years

Journal of Telecommunications and Information Technology, 2004
We consider the optimization problems which may be solved by the direct decomposition method. It is possible when the performance index is a monotone function of other performance indices, which depend on two subsets of decision variables: an individual
Andrzej Karbowski
doaj   +1 more source