Results 81 to 90 of about 327,426 (292)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Nonlinear Dynamic Analysis of the Cutting Process of a Nonextensible Composite Boring Bar
Shock and Vibration, 2020 A nonlinear dynamic analysis of the cutting process of a nonextensible composite cutting bar is presented. The cutting bar is simplified as a cantilever with plane bending.
Bole Ma, Yongsheng Ren
doaj +1 more source
Strain Rate of Metal Deformation in the Machining Process from a Fluid Flow Perspective
Applied Sciences, 2020 Metal cutting speeds are getting faster with the development of high-speed cutting technology, and with the increase in cutting speed, the strain rate will become larger, which makes the study of the metal cutting process more inconvenient.
Keguo Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Displacements analysis of self-excited vibrations in turning
, 2009 The actual research deals with determining by a new protocol the necessary parameters considering a three-dimensional model to simulate in a realistic way the turning process on machine tool.
A Cowley +26 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Initial Tool Orientation Set-up for 5-Axis Flank Milling Based on Faceted Models
MATEC Web of Conferences, 2017 One of the factors affecting the effectiveness of machining time of 5-axis miling is the method being used. By using flank milling method, as one of the optimized processes to make a workpiece, the time required for the process becomes shorter.This ...
Kiswanto Gandjar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Models and Methods for Merge-In-Transit Operations [PDF]
, 2001 We develop integer programming formulations and solution methods for addressing operational issues in merge-in-transit distribution systems. The models account for various complex problem features including the integration of inventory and transportation
Croxton, Keely L. +2 more
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