Results 21 to 30 of about 42,783 (266)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Load Characteristics in the Cutting of Three Types of Bauxite by Conical Picks

Applied Sciences
Underground bauxite comprehensive mechanized mining has attracted growing attention, yet regional differences in bauxite characteristics challenge its applicability and economic efficiency. The conical pick, a key cutting tool for this mining method, has
Weipeng Xu, Bin Zhang, Nangeng Yue, Kuidong Gao, Ziyao Ma, Shengru Zhang, Xiaodi Zhang, Yu Bu   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Instantaneous contact area-based model for shear strength sensitive cutting coefficients characterization of anisotropic parts

Engineering Science and Technology, an International Journal
The anisotropic nature of laser powder bed fusion (LPBF) parts means that the cutting force coefficients obtained by linear regression or non-linear optimization methods only work for one tool position relative to the workpiece. These methods must obtain
José David Pérez-Ruiz, Luis Norberto López de Lacalle, Gorka Urbikain, Hugo Álvarez, Jovanny Pacheco   +4 more
doaj   +1 more source

Enhancing the Dynamic Stability of Pylons via Their Drag and Lift Coefficients by Finite Volume Method

Buildings, 2023
This study aimed to estimate the drag and lift coefficients of the long-span bridge pylon using the finite volume method (FVM). The k-ω turbulence model was applied to analyze the behavior of wind flow around the pylon, yielding drag and lift coefficient
Van My Nguyen, Van Than Chau
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Using regression analysis method to model and optimize the quality of chip-removing processed metal surfaces

MATEC Web of Conferences, 2017
The paper aim is to identify based on regression analysis, the quantitative relationship between the cutting process parameters (cutting speed, cutting depth and feed per tooth) and the arithmetic mean deviation of the surface profile, measured ...
Țîțu Mihail Aurel, Pop Alina Bianca
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Diagnostics of Breakdown of Cutting Tools of Axial Cutting Head of the П110-04 Type Heading Machine

Management Systems in Production Engineering, 2017
The operation of a heading machine with an out-of-work cutting tool can cause essential reduction of the machine element resource. The diagnostics of the cutting tool breakdown on the longitudinal axial cutting head in the real - time mode can be ...
Shabaev О. Е., Bridun I. I., Moroz О. К.   +2 more
doaj   +1 more source

Physics-Based Simulations of Chip Flow over Micro-Textured Cutting Tool in Orthogonal Cutting of Alloy Steel

Journal of Manufacturing and Materials Processing, 2021
Physics-based process simulations have the potential to allow virtual process design and the development of digital twins for smart machining applications.
Kaushalendra V. Patel, Krzysztof Jarosz, Tuğrul Özel   +2 more
doaj   +1 more source