Results 121 to 130 of about 1,349,956 (360)

Assessment of Machinability of Ti6Al4V Alloy Under Dry Conditions [PDF]

open access: yesMATEC Web of Conferences
Titanium alloys pose significant challenges during machining, necessitates a thorough investigation into the impact of process parameters on machining Ti6Al4V alloy.
Younas Muhammad   +3 more
doaj   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

EXPERIMENTAL STUDY ON CUTTING ENERGY CONSUMPTION OF COAL MINING UNDER DIFFERENT WORKING CONDITIONS

open access: yesJixie qiangdu, 2019
In order to study the cutting energy consumption characteristics of coal miner under complicated conditions, the MG500/1180-WD shearer was cut out under different working conditions by collecting the cutting energy consumption model of coal mining ...
HAO ZhiYong   +3 more
doaj  

Assessment of Cutting Tool Condition by Acoustic Emission

open access: yesProcedia Materials Science, 2012
AbstractAcoustic emission (AE) signals, generated during the machining of steel, were analyzed in order to extract information about the condition of the cutting tool. Drill bits with different cutting edge conditions were used to drill steel specimens while registering the AE generated during cutting.
José Ruzzante   +3 more
openaire   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

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