Results 121 to 130 of about 1,433,621 (312)

EXPERIMENTAL STUDY ON CUTTING ENERGY CONSUMPTION OF COAL MINING UNDER DIFFERENT WORKING CONDITIONS

Jixie qiangdu, 2019
In order to study the cutting energy consumption characteristics of coal miner under complicated conditions, the MG500/1180-WD shearer was cut out under different working conditions by collecting the cutting energy consumption model of coal mining ...
HAO ZhiYong, ZHOU ZhengQi, ZHANG Pei, YANG QuanChun   +3 more
doaj  

Performance comparison and prediction of cutting energy of new cemented carbide micro-pit turning tool

工程科学学报, 2017
Cutting energy can be transformed into cutting heat, which directly affects the cutting temperature. Therefore, it is important to understand the generation, transfer, and transformation of cutting energy to cutting temperature.
ZHAN Gang, HE Lin, JIANG Hong-wan, ZOU Zhong-fei   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Assessment of Machinability of Ti6Al4V Alloy Under Dry Conditions [PDF]

MATEC Web of Conferences
Titanium alloys pose significant challenges during machining, necessitates a thorough investigation into the impact of process parameters on machining Ti6Al4V alloy.
Younas Muhammad, Mohammed Sambo Abdulkadir, Asim Taimoor, Saharudin Shahneel   +3 more
doaj   +1 more source

TiNbN Hard Coating Deposited at Varied Substrate Temperature by Cathodic Arc: Tribological Performance under Simulated Cutting Conditions. [PDF]

Materials (Basel), 2023
Gonzalez-Carmona JM, Mambuscay CL, Ortega-Portilla C, Hurtado-Macias A, Piamba JF.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Characterization of Si and SiO₂ in Dust Emitted during Granite Polishing as a Function of Cutting Conditions. [PDF]

Materials (Basel), 2022
Kouam J, Songmene V, Bahloul A, Samuel AM.   +3 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Optimization and Sensitivity Analysis of the Cutting Conditions in Rough, Semi-Finish and Finish Honing. [PDF]

Materials (Basel), 2021
Buj-Corral I, Rodero-de-Lamo L, Marco-Almagro L.   +2 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source