Results 121 to 130 of about 8,660,062 (300)

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Experimental Investigation of Suitable Cutting Conditions of Dry Drilling into High-Strength Structural Steel. [PDF]

open access: yesMaterials (Basel), 2021
Pelikán L   +5 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Considerations for Discrete Element Modeling of Rock Cutting [PDF]

open access: yes, 2013
This study attempts to build a framework within the Discrete Element Method (DEM) to produce a reliable predictive tool in rock cutting applications, such that the cutting forces and fragmentation process are reasonably estimated. The study is limited to
Mendoza Rizo, Jorge Alejandro
core  

Method for an Effective Selection of Tools and Cutting Conditions during Precise Turning of Non-Alloy Quality Steel C45. [PDF]

open access: yesMaterials (Basel), 2022
Ivchenko O   +7 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Portrait of Rex Nan Kivell aged 30, London, 1930 [picture] /

open access: yes, 1930
Title devised by catalgouer from inscription.; Inscriptions: "Fenwick Cutting London"--Below image; "Print 1975/3 Item 11805; RNK at age of 30 when he was collecting Australiana"--In ink and pencil on verso.; Condition: Faded, yellowing, silvering, tears.
Cutting, Fenwick.
core  

Corrosion Resistance and Surface Bioactivity of Ti6Al4V Alloy after Finish Turning under Ecological Cutting Conditions. [PDF]

open access: yesMaterials (Basel), 2021
Leksycki K   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

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