Results 51 to 60 of about 385,035 (296)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Controllable Preparation and Strengthening Strategies towards High-Strength Carbon Nanotube Fibers

Nanomaterials, 2022
Carbon nanotubes (CNTs) with superior mechanical properties are expected to play a role in the next generation of critical engineering mechanical materials.
Yukang Zhu, Hongjie Yue, Muhammad Junaid Aslam, Yunxiang Bai, Zhenxing Zhu, Fei Wei   +5 more
doaj   +1 more source

Theoretical Estimate of the Effect of the Parameters of the Circulating Movement of the Workpiece on the Intensity of Its Cutting. [PDF]

, 2014
Рассматривается проблема повышения интенсивности распиливания при сообщении эллиптического движения распиливаемой заготовке. В ходе проведения исследования получены зависимости величины импульса ударной силы, действующего в процессе ударно-фрикционного ...
Габец, В. Л., Дроздов, А. В., Киселев, М. Г., Ямная, Д. А.   +3 more
core  

The influence of laser assistance on the machinability of the titanium alloy Ti555-3 [PDF]

, 2013
The Ti533-3 alloy is a new titanium alloy which is starting to see increased use in the aeronautical domain to improve the durability of components and to optimize the weight/resistance ratio. This alloy is characterized by greater resistance compared to
BRAHAM-BOUCHNAK, Tarek, GERMAIN, Guénaël, LEBRUN, Jean-Lou, MOREL, Anne   +3 more
core   +5 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Simulation and Experimental Study on the Effect of Edge Radius on the Cutting Condition of Carbide Inserts

Machines
Carbide tools are extensively used in the automotive, aerospace, and marine industries. However, an unsuitable tool-edge treatment can affect the cutting performance of carbide tools.
Shitao Chen, Zhiyuan Bao, Yuhong Yan, Binghai Lyu, Hongyu Chen, Wei Hang, Jinhu Wang, Wenhong Zhao, Julong Yuan, Xu Wang   +9 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Cemented Carbide End-Mill Edge Preparation Using Dry-Electropolishing

Journal of Manufacturing and Materials Processing
Precision edge preparation techniques for cemented carbides enable optimization of the geometry of tools’ cutting edges. These techniques are frequently used in high-stress environments, resulting in substantial improvements in tools’ cutting performance.
Guiomar Riu-Perdrix, Andrea Valencia-Cadena, Luis Llanes, Joan Josep Roa   +3 more
doaj   +1 more source