Results 81 to 90 of about 385,035 (296)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cement-Based Thermoelectric Materials, Devices and Applications
Nano-Micro LettersHighlights Covering the most cutting-edge advances in cement-based thermoelectric materials. The first systematic summary of the preparation, performance and functional applications of cement-based thermoelectric devices.
Wanqiang Li +3 more
doaj +1 more source
Topological model for machining of parts with complex shapes [PDF]
, 2012 Complex shapes are widely used to design products in several industries such as aeronautics, automotive and domestic appliances. Several variations of their curvatures and orientations generate difficulties during their manufacturing or the machining of ...
Bernard, Alain +2 more
core +2 more sources
Aerogel keystones: extraction of complete hypervelocity impact events from aerogel collectors
, 2003 In January 2006, the Stardust mission will return the first samples from a solid solar-system body since Apollo, and the first samples of contemporary interstellar dust ever collected.
Brennan +10 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Sustainable machining - correlation of the optimization by minimum energy, minimum manufacturing time and cost of production [PDF]
, 2013 The machining process leads the indices of productivity and employability in a world level and has an enormous influence at social and economics standards, however it requires machinery that consume high levels of energy, chemical fluids and has great ...
Pascoal, Filipa, Silveira, José
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Colour Changes In Lizards, Particularly In Phrynosoma [PDF]
, 1938 The activities of the melanophore system of Phrynosoma in comparison with that of Chamaeleo may be stated categorically in the following way. I. The blanching of Phrynosoma blainvillii is due (1) to the action of its concentrating nerve-fibres on ...
Parker, G. H.
core
Procedia Engineering, 2014 AbstractThis article deals with the influence of cutting edge preparation and cutting edge radius on tool life, cutting forces and the roughness of machined surface. The cutting edge preparation was done on the inserts with wiper geometry which are used during machining of dividing plane at a steam turbine casing.
Fulemova, Jaroslava, Janda, Zdeněk
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source