Results 161 to 170 of about 2,078,237 (349)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Discussing the Cutting Method of Skew Bevel Bear based on the Tooth Surface Generating Line
Jixie chuandong, 2020 The principle of tooth surface generating of skew bevel gear is analyzed about spherical involute， based on the theory that the line which in the plane that is tangent with the base cone of the skew bevel gear roll on the cone surface absolutely， a new ...
Baichao Wang +4 more
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Finite element simulations of conventional and ultrasonically assisted turning processes with plane and textured cutting inserts [PDF]
, 2019 This paper investigates the performance of conventional turning and ultrasonically assisted turning (UAT) processes with plane and textured cutting inserts.
Anish Roy (1256436) +4 more
core
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Shape Analysis of the Patellar Bone Surface and Cutting Plane for Knee Replacement Surgery. [PDF]
Comput Math Methods Med, 2018 Rex EL +5 more
europepmc +1 more source
Modelling the cutting process and cutting performance in abrasive waterjet machining with controlled nozzle oscillation [PDF]
, 2006 Abrasive waterjet (AWJ) cutting is one of the most recently developed manufacturing technologies. It is superior to many other cutting techniques in processing various materials, particularly in processing difficult-to-cut materials.
Xu, Shunli
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Interior Point Cutting Plane Methods in Integer Programming [PDF]
, 2011 This thesis presents novel approaches that use interior point concepts in solving mixed integer programs. Particularly, we use the analytic center cutting plane method to im-prove three of the main components of the branch-and-bound algorithm: cutting ...
Joe Naoum-Sawaya, Naoum-Sawaya, Joe
core