Results 61 to 70 of about 1,171,807 (293)

Cutting Planes for Signomial Programming

SIAM Journal on Optimization
Cutting planes are of crucial importance when solving nonconvex nonlinear programs to global optimality, for example using the spatial branch-and-bound algorithms. In this paper, we discuss the generation of cutting planes for signomial programming. Many global optimization algorithms lift signomial programs into an extended formulation such that these
Liding Xu, Claudia D'Ambrosio, Leo Liberti, Sonia Haddad-Vanier   +3 more
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

On the complexity of cutting-plane proofs

Discrete Applied Mathematics, 1987
As introduced by \textit{V. Chvatal} [Discrete Math. 4, 305-337 (1973; Zbl 0253.05131)] cutting planes provide a canonical way of proving that every integral solution of a given system of linear inequalities satisfies another specified inequality. In this note we make several observations on the complexity of such proofs in general and when restricted ...
William J. Cook, Collette R. Coullard, György Turán   +2 more
openaire   +3 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A new three‐dimensional patient‐specific cutting guide for opening wedge high tibial osteotomy based on ct scan: preliminary in vitro results

Journal of Experimental Orthopaedics, 2023
Purpose The aim of this study was to evaluate the accuracy of a patient‐specific cutting guide on both coronal and sagittal alignment compared to the pre‐operative planning in OWHTO.
Federica Rosso, Roberto Rossi, Philippe Neyret, Robert Śmigielski, Jacques Menetrey, Davide Edoardo Bonasia, Sandro Franco Fucentese   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Experimental Analysis and Geometrical Modeling of Cutting Conditions Effect in 5 Axis Milling with Ti6Al4V Alloy [PDF]

, 2012
The 5 axis continuous milling is an advanced technique for free-form surfaces manufacturing. In finishing, this technique uses ball-end or hemispherical milling cutter.
PRAT, David, FROMENTIN, Guillaume, DUC, Emmanuel, POULACHON, Gerard   +3 more
core   +1 more source

Theoretical and Experimental Verification of Dynamic Behaviour of a Guided Spline Arbor Circular Saw

Shock and Vibration, 2017
An analysis of the dynamic and stability characteristics of a guided wood cutting spline arbor circular saw is presented. A multibody dynamic model is developed to consider the idling and cutting characteristics.
Ahmad Mohammadpanah, Stanley G. Hutton
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Primal cutting plane algorithms revisited

, 2002
Dual fractional cutting plane algorithms, in which cutting planes are used to iteratively tighten a linear relaxation of an integer program, are well known and form the basis of the highly successful branch-and-cut method.
Lodi, A., Letchford, A. N.
core   +6 more sources