Results 91 to 100 of about 904,011 (327)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Nonlinear Dynamic Analysis of the Cutting Process of a Nonextensible Composite Boring Bar

Shock and Vibration, 2020
A nonlinear dynamic analysis of the cutting process of a nonextensible composite cutting bar is presented. The cutting bar is simplified as a cantilever with plane bending.
Bole Ma, Yongsheng Ren
doaj   +1 more source

Strain Rate of Metal Deformation in the Machining Process from a Fluid Flow Perspective

Applied Sciences, 2020
Metal cutting speeds are getting faster with the development of high-speed cutting technology, and with the increase in cutting speed, the strain rate will become larger, which makes the study of the metal cutting process more inconvenient.
Keguo Zhang, Keyi Wang, Zhanqiang Liu, Xiaodong Xu   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Displacements analysis of self-excited vibrations in turning

, 2009
The actual research deals with determining by a new protocol the necessary parameters considering a three-dimensional model to simulate in a realistic way the turning process on machine tool.
A Cowley, A Moufki, Alain Gérard, AV Dassanayake, C Mei, CF Bisu, CK Chen, Claudiu F. Bisu, DA Axinte, DE Dimla Sr, HE Merrit, I Marinescu, IN Tansel, JD Calderon-Najera, Jean-Yves K’nevez, K Liu, LZ Qiang, M Thomas, O Cahuc, O Cahuc, PG Benardos, Philippe Darnis, RL Kegg, W Grzeski, X Li, Y Sahin, YS Chiou   +26 more
core   +1 more source

Initial Tool Orientation Set-up for 5-Axis Flank Milling Based on Faceted Models

MATEC Web of Conferences, 2017
One of the factors affecting the effectiveness of machining time of 5-axis miling is the method being used. By using flank milling method, as one of the optimized processes to make a workpiece, the time required for the process becomes shorter.This ...
Kiswanto Gandjar, Baskoro Ario Sunar, Syaefudin Eko Arif   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Models and Methods for Merge-In-Transit Operations [PDF]

, 2001
We develop integer programming formulations and solution methods for addressing operational issues in merge-in-transit distribution systems. The models account for various complex problem features including the integration of inventory and transportation
Croxton, Keely L., Gendon, Bernard, Magnanti, Thomas L.   +2 more
core