Results 101 to 110 of about 837,325 (362)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Initial Tool Orientation Set-up for 5-Axis Flank Milling Based on Faceted Models
MATEC Web of Conferences, 2017 One of the factors affecting the effectiveness of machining time of 5-axis miling is the method being used. By using flank milling method, as one of the optimized processes to make a workpiece, the time required for the process becomes shorter.This ...
Kiswanto Gandjar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Models and Methods for Merge-In-Transit Operations [PDF]
, 2001 We develop integer programming formulations and solution methods for addressing operational issues in merge-in-transit distribution systems. The models account for various complex problem features including the integration of inventory and transportation
Croxton, Keely L. +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A new cutting plane method for lexicographic multi-objective integer linear programming
, 2023 Marco Cococcioni +4 more
openalex +2 more sources
A Theoretical Study on the use of Passive Soil Resistance in Winch Anchor Design [PDF]
, 1983 This paper describes work being carried out to determine the length and depth of a cutting blade required to support a rescue vehicle fitted with a winch. Analytical work described relates mostly to the suitability of blade used.
Ahmad, Desa
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2012 This paper presents a 2D convergence density criterion for minimizing the total junction delay at isolated junctions in the lane-based optimization framework.
C. K. Wong, Y. Y. Lee
doaj +1 more source