Results 121 to 130 of about 837,325 (362)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Optically induced fabrication of three-dimensional photonic lattice microstructures by using cutting-combination lens

Results in Physics
A convenient method for producing three-dimensional photonic lattice microstructures was experimentally demonstrated by using a cutting-combination lens.
Wentao Jin, Shaochun Fu, Longsheng Liu, Wencheng Hu, Meng Song, Ying Guo, Xiaohong Sun, Rui Sun   +7 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Integer Programming by Cutting Planes Methods

, 1973
Linear programming is a relatively new, very important branch of modern mathematics and is about twenty five years old. In this day and age, most planners and decision makers will acknowledge that some linear optimization problems are worth the expense and trouble to solve.
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A two-cut approach in the analytic center cutting plane method

, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Goffin, Jean-louis, Vial, Jean-Philippe
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Justification of Parameters of a Prismatic Device for Fertiliser Distribution Across the Width of the Sub-Blade Area of a Flat-Cutting Working Body

Acta Technologica Agriculturae
Subsurface application of mineral fertilisers is an effective agricultural technique that improves both the quantity and quality of cultivated crops. To ensure uniform distribution of granular mineral fertilisers across the width of a tillage working ...
Kuvaev Anton Nikolaevich, Derepaskin Alexey Ivanovich, Tokarev Ivan Vladimirovich, Polichshuk Yurij Vladimirovich, Binyukov Yurij Viktorovich, Ivanchenko Pavel Grigoryevich, Semibalamut Alexander Viktorovich   +6 more
doaj   +1 more source

A New Cutting Strategy to Reduce Plasticity Errors in Measuring Welding Residual Stress via the Contour Method

Journal of Manufacturing and Materials Processing
The Contour Method is a well-established destructive technique for determining cross-sectional maps of residual stress in manufactured metallic components. The validity of the technique is dependent on linear elastic relaxation of residual strains across
Sanjooram Paddea, Ruiyao Zhang, Xiaodong Hou, Fan Yang, Wenchao Dong, Shanping Lu, Peter John Bouchard, Shuyan Zhang   +7 more
doaj   +1 more source