Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz +8 more
wiley +1 more source
Block identification and stability analysis of underground stope with multi-working face. [PDF]
Zhang M +7 more
europepmc +1 more source
Clinical Validation of Plasma p‐217tau in Neurological Diseases
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi +13 more
wiley +1 more source
Favorable midterm clinical results of medial unicompartmental knee arthroplasty guided by coronal limb alignment using an image-free navigation system. [PDF]
Shimozaki K, Shimozaki S, Shimozaki E.
europepmc +1 more source
A probabilistic analytic center cutting plane method for feasibility of uncertain LMIs
G. Calafiore, F. Dabbene
semanticscholar +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Reducing unintended valgus deformity after supracondylar femoral derotational osteotomy: Influence of derotation amount and osteotomy method based on femoral antecurvature. [PDF]
Park J +5 more
europepmc +1 more source
A logarithmic barrier cutting plane method for convex programming. [PDF]
Hertog, D. den +3 more
core +1 more source
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
Customized positioning of the glenoid component in reverse shoulder arthroplasty: a new computer aided design methodology. [PDF]
Cirello A +8 more
europepmc +1 more source

