Results 71 to 80 of about 904,011 (327)

Analyzing orthogonal cutting process using SPH method by kinematic cutting tool

Comptes Rendus. Mécanique, 2020
In this paper, the orthogonal cutting process is studied using Smooth Particle Hydrodynamic (SPH) method by a kinematic rigid cutting tool and two work-piece material models: perfectly elastic-plastic (EPP) model and Johnson–Cook (JC) model.
Dehghani, Mohammad, Shafiei, Alireza, Abootorabi, Mohammad Mahdi   +2 more
doaj   +1 more source

An Adaptive Proximal Bundle Method with Inexact Oracles for a Class of Nonconvex and Nonsmooth Composite Optimization

Mathematics, 2021
In this paper, an adaptive proximal bundle method is proposed for a class of nonconvex and nonsmooth composite problems with inexact information. The composite problems are the sum of a finite convex function with inexact information and a nonconvex ...
Xiaoliang Wang, Liping Pang, Qi Wu, Mingkun Zhang   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Training linear ranking SVMs in linearithmic time using red-black trees

, 2011
We introduce an efficient method for training the linear ranking support vector machine. The method combines cutting plane optimization with red-black tree based approach to subgradient calculations, and has O(m*s+m*log(m)) time complexity, where m is ...
Antti Airola, Bayer, Bottou, Bradley, Burges, Chapelle, Chapelle, Cormen, Cortes, Cortes, Drucker, Franc, Freund, Fürnkranz, Hanley, Herbrich, Joachims, Joachims, Joachims, Joachims, Lewis, Liu, Pahikkala, Poggio, Provost, Smola, Tapio Pahikkala, Tapio Salakoski, Teo, Teo, Tsochantaridis, Waegeman, Williams   +32 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Discussing the Cutting Method of Skew Bevel Bear based on the Tooth Surface Generating Line

Jixie chuandong, 2020
The principle of tooth surface generating of skew bevel gear is analyzed about spherical involute， based on the theory that the line which in the plane that is tangent with the base cone of the skew bevel gear roll on the cone surface absolutely， a new ...
Baichao Wang, Xianting Lu, Litong Zhang, Zhenquan Xu, Xue Zhang   +4 more
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Quadratic stabilization of Benders decomposition [PDF]

, 2014
The foundational Benders decomposition, or variable decomposition, is known to have the inherent instability of cutting plane-based methods. Several techniques have been proposed to improve this method, which has become the state of the art for important
Malick, Jérôme, Zaourar, Sofia
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Incremental cutting-plane method and its application

, 2021
We consider regularized cutting-plane methods to minimize a convex function that is the sum of a large number of component functions. One important example is the dual problem obtained from Lagrangian relaxation on a decomposable problem. In this paper, we focus on an incremental variant of the regularized cutting-plane methods, which only evaluates a ...
Sugishita, Nagisa, Grothey, Andreas, McKinnon, Ken   +2 more
openaire   +2 more sources